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2008 | 55 | 2 | 411-415
Article title

Overexpression of human CUTA isoform2 enhances the cytotoxicity of copper to HeLa cells

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Languages of publication
EN
Abstracts
EN
Copper, an essential transient element, can be toxic to cells when present in excess. Altered copper homeostasis is involved in pathological events of many diseases. Human CUTA isoform2 is a member of cation tolerance protein (CutA1) family. In this study, we examined the effect of CUTA isoform2 overexpression on copper toxicity. It was shown that overexpressed CUTA isoform2 sensitized HeLa cells to copper toxicity by promoting copper-induced apoptosis. The inhibition effect of excessive copper on cell proliferation was also enhanced by overexpressed CUTA isoform2. So CUTA isoform2 was implicated to be involved in the cytotoxicity of copper.
Publisher

Year
Volume
55
Issue
2
Pages
411-415
Physical description
Dates
published
2008
received
2008-01-31
revised
2008-05-13
accepted
2008-06-11
(unknown)
2008-06-14
Contributors
author
  • State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai, P. R. China
author
  • State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai, P. R. China
author
  • State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai, P. R. China
author
  • School of Life Science, Soochow University, Soochow, P. R. China
author
  • State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai, P. R. China
author
  • State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai, P. R. China
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv55p411kz
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