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2008 | 55 | 2 | 227-240
Article title

Lysophosphatidic acids, cyclic phosphatidic acids and autotaxin as promissing targets in therapies of cancer and other diseases

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Abstracts
EN
Lysophospholipids have long been recognized as membrane phospholipid metabolites, but only recently lysophosphatidic acids (LPA) have been demonstrated to act on specific G protein-coupled receptors. The widespread expression of LPA receptors and coupling to several classes of G proteins allow LPA-dependent regulation of numerous processes, such as vascular development, neurogenesis, wound healing, immunity, and cancerogenesis. Lysophosphatidic acids have been found to induce many of the hallmarks of cancer including cellular processes such as proliferation, survival, migration, invasion, and neovascularization. Furthermore, autotaxin (ATX), the main enzyme converting lysophosphatidylcholine into LPA was identified as a tumor cell autocrine motility factor. On the other hand, cyclic phosphatidic acids (naturally occurring analogs of LPA generated by ATX) have anti-proliferative activity and inhibit tumor cell invasion and metastasis. Research achievements of the past decade suggest implementation of preclinical and clinical evaluation of LPA and its analogs, LPA receptors, as well as autotaxin as potential therapeutic targets.
Publisher

Year
Volume
55
Issue
2
Pages
227-240
Physical description
Dates
published
2008
received
2008-03-17
revised
2008-05-20
accepted
2008-05-30
(unknown)
2008-06-14
Contributors
  • Institute of Technical Biochemistry, Faculty of Biotechnology and Food Sciences, Technical University of Łódź, Łódź, Poland
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YADDA identifier
bwmeta1.element.bwnjournal-article-abpv55p227kz
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