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2008 | 55 | 1 | 207-213
Article title

Homologues of HSV-1 nuclear egress factor UL34 are potential phosphoinositide-binding proteins

Content
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EN
Abstracts
EN
During the herpesvirus replication cycle, viral transcription, DNA replication, formation of capsids and DNA packaging occur in the nucleus. The subsequent nuclear egress of newly synthesized nucleocapsids is performed by budding of the inner leaflet of the nuclear membrane, which creates the primary envelope. Although products of two genes conserved throughout the Herpesviridae family (HSV-1 UL34 and UL31) have previously been shown to be involved in the execution of this process, the molecular basis of their activity is not clear. Here we present results of protein structure prediction for the conserved domain of UL34. The applied methodology suggests that this protein adopts a pleckstrin homology (PH) fold to perform its function. A detailed inspection of the ligand binding site strongly supports the hypothesis that UL34 orthologs can recognize phosphoinositides. Since previous works suggest that alterations of UL34 gene product result in a drastic impairment of primary envelopment of HSV-1 and trapping of capsids in the nucleus, the presented data may lead to the development of novel anti-herpetic therapeutic strategies where analogs of phosphoinositides are administered.
Publisher

Year
Volume
55
Issue
1
Pages
207-213
Physical description
Dates
published
2008
received
2008-01-04
revised
2008-02-18
accepted
2008-02-27
(unknown)
2008-03-04
Contributors
  • Department of Gastroenterology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warszawa, Poland
  • Institute of Plant Genetics, Poznań, Poland
  • BioInfoBank Institute, Poznań, Poland
References
  • Altschul S, Madden T, Schäffer A, Zhang J, Zhang Z, Miller W, Lipman D (1997) Nucleic Acids Res 25: 3389-3402.
  • Bjerke SL, Cowan JM, Kerr JK, Reynolds AE, Baines JD, Roller RJ (2003) J Virol 77: 7601-7610.
  • Bujnicki J, Elofsson A, Fischer D, Rychlewski L (2001) Bioinformatics 17: 750-751.
  • Carpten JD, Faber AL, Horn C, Donoho GP, Briggs SL, Robbins CM, Hostetter G, Boguslawski S, Moses TY, Savage S, Uhlik M, Lin A, Du J, Qian YW, Zeckner DJ, Tucker-Kellogg G, Touchman J, Patel K, Mousses S, Bittner M, Schevitz R, Lai MH, Blanchard KL, Thomas JE (2007) Nature 448: 439-444.
  • Cozier GE, Carlton J, Bouyoucef D, Cullen PJ (2004) Curr Top Microbiol Immunol 282: 49-88.
  • Diella F, Gould CM, Chica C, Via A, Gibson TJ (2008) Nucleic Acids Res 36: D240-244.
  • Dygas A, Baranska J (2001) Acta Biochim Polon 48: 541-549.
  • Finn R, Mistry J, Schuster-Bockler B, Griffiths-Jones S, Hollich V, Lassmann T, Moxon S, Marshall M, Khanna A, Durbin R, Eddy S, Sonnhammer E, Bateman A (2006) Nucleic Acids Res 34: D247-D251.
  • Fischer D (2003) Proteins 51: 434-441.
  • Fuchs W, Klupp BG, Granzow H, Osterrieder N, Mettenleiter TC (2002) J Virol 76: 364-378.
  • Ginalski K, Elofsson A, Fischer D, Rychlewski L (2003) Bioinformatics 19: 1015-1018.
  • Ginalski K, von Grotthuss M, Grishin N, Rychlewski L (2004) Nucleic Acids Res 32: W576-W581.
  • Ginalski K, Grishin N, Godzik A, Rychlewski L (2005) Nucleic Acids Res 33: 1874-1891.
  • Haslam RJ, Koide HB, Hemmings BA (1993) Nature 363: 309-310.
  • Inglese J, Koch WJ, Touhara K, Lefkowitz RJ (1995) Trends Biochem Sci 20: 151-156.
  • Jaroszewski L, Rychlewski L, Li Z, Li W, Godzik A (2005) Nucleic Acids Res 33: W284-W288.
  • Kelley L, MacCallum R, Sternberg M (2000) J Mol Biol 299: 499-520.
  • Klupp BG, Granzow H, Mettenleiter TC (2001) J Gen Virol 82: 2363-2371.
  • Koczyk G, Wyrwicz LS, Rychlewski L (2007) J Mol Model 13: 445-455.
  • Lemmon MA (2003) Traffic 4: 201-213.
  • Lemmon MA, Ferguson KM, Abrams CS (2002) FEBS Lett 513: 71-76.
  • Li W, Godzik A (2006) Bioinformatics 22: 1658-1659.
  • Liang L, Baines JD (2005) J Virol 79: 3797-3806.
  • Linding R, Russell R, Neduva V, Gibson T (2003) Nucleic Acids Res 31: 3701-3708.
  • McGuffin L, Bryson K, Jones D (2000) Bioinformatics 16: 404-405.
  • Mettenleiter TC (2002) J Virol 76: 1537-1547.
  • Mettenleiter TC (2004) Virus Res 106: 167-180.
  • Mettenleiter TC, Klupp BG, Granzow H (2006) Curr Opin Microbiol 9: 423-429.
  • Nawaratne R, Gray A, Jorgensen CH, Downes CP, Siddle K, Sethi JK (2006) Mol Endocrinol 20: 1838-1852.
  • Ogg PD, McDonell PJ, Ryckman BJ, Knudson CM, Roller RJ (2004) Virology 319: 212-224.
  • Powis G, Berggren M, Gallegos A, Frew T, Hill S, Kozikowski A, Bonjouklian R, Zalkow L, Abraham R, Ashendel C et al. (1995) Acta Biochim Polon 42: 395-403.
  • Reynolds AE, Ryckman BJ, Baines JD, Zhou Y, Liang L, Roller RJ (2001) J Virol 75: 8803-8817.
  • Reynolds AE, Wills EG, Roller RJ, Ryckman BJ, Baines JD (2002) J Virol 76: 8939-8952.
  • Rost B, Sander C (1993) Proc Natl Acad Sci USA 90: 7558-7562.
  • Ryckman BJ, Roller RJ (2004) J Virol 78: 399-412.
  • Saraste M, Hyvonen M (1995) Curr Opin Struct Biol 5: 403-408.
  • Scott ES, O'Hare P (2001) J Virol 75: 8818-8830.
  • Takenawa T, Itoh T (2006) IUBMB Life 58: 296-303.
  • Thomas CC, Deak M, Alessi DR, van Aalten DM (2002) Curr Biol 12: 1256-1262.
  • Thompson J, Higgins D, Gibson T (1994) Nucleic Acids Res 22: 4673-4680.
  • von Grotthuss M, Pas J, Wyrwicz L, Ginalski K, Rychlewski L (2003) Proteins 53: 418-423.
  • Weglarz L, Molin I, Orchel A, Parfiniewicz B, Dzierzewicz Z (2006) Acta Biochim Polon 53: 349-356.
  • Wyrwicz LS, Rychlewski L (2007a) Acta Biochim Polon 54: 551-559.
  • Wyrwicz LS, Rychlewski L (2007b) Antiviral Res 75: 83-86.
  • Wyrwicz LS, Rychlewski L (2007c) Antiviral Res 75: 167-172.
  • Wyrwicz LS, Rychlewski L (2008) Acta Biochim Polon 55: 67-73.
  • Wyrwicz L, Koczyk G, Rychlewski L, Plewczynski D (2007) J Physics Cond Mat 19: 285222/1-8.
  • Wyrwicz LS, Ginalski K, Rychlewski L (2008) Cell Cycle 7: 269-271.
  • Yan J, Wen W, Xu W, Long JF, Adams ME, Froehner SC, Zhang M (2005) Embo J 24: 3985-3995.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv55p207kz
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