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Number of results
2007 | 54 | 4 | 857-861

Article title

The Suzuki-Miyaura reaction in the chemical transformations of vindoline

Content

Title variants

Languages of publication

EN

Abstracts

EN
Vindoline and its analogues are important constituents of the Madagascan periwinkle Catharanthus roseus, and some of them are valuable chemotherapy drugs used in treatment for some types of cancer, including leukaemia, lymphoma, breast and lung cancer. The search for semi-synthetic congeners of natural substances is still an important task for organic chemistry. In this communication we report the synthesis of five new vindoline derivatives, 15-(2-methoxyphenyl)vindoline 11, 15-(3-methoxyphenyl)vindoline 12, 15-(2-nitrophenyl)vindoline 13, 15-(3-cyanophenyl)vindoline 15, and 15-(4-cyanophenyl)vindoline 16 using the Suzuki-Miyaura reaction as the key step. X-Ray analysis of compound 16 is also reported.

Year

Volume

54

Issue

4

Pages

857-861

Physical description

Dates

published
2007
received
2007-07-17
revised
2007-09-23
accepted
2007-09-24
(unknown)
2007-12-08

Contributors

  • Faculty of Chemistry, Warsaw University, Warszawa, Poland
  • Faculty of Chemistry, Warsaw University, Warszawa, Poland
author
  • Faculty of Chemistry, Warsaw University, Warszawa, Poland
author
  • National Medicines Institute, Warszawa, Poland
  • Faculty of Chemistry, Warsaw University, Warszawa, Poland
  • Faculty of Chemistry, Warsaw University, Warszawa, Poland

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.bwnjournal-article-abpv54p857kz
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