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2007 | 54 | 4 | 857-861
Article title

The Suzuki-Miyaura reaction in the chemical transformations of vindoline

Content
Title variants
Languages of publication
EN
Abstracts
EN
Vindoline and its analogues are important constituents of the Madagascan periwinkle Catharanthus roseus, and some of them are valuable chemotherapy drugs used in treatment for some types of cancer, including leukaemia, lymphoma, breast and lung cancer. The search for semi-synthetic congeners of natural substances is still an important task for organic chemistry. In this communication we report the synthesis of five new vindoline derivatives, 15-(2-methoxyphenyl)vindoline 11, 15-(3-methoxyphenyl)vindoline 12, 15-(2-nitrophenyl)vindoline 13, 15-(3-cyanophenyl)vindoline 15, and 15-(4-cyanophenyl)vindoline 16 using the Suzuki-Miyaura reaction as the key step. X-Ray analysis of compound 16 is also reported.
Year
Volume
54
Issue
4
Pages
857-861
Physical description
Dates
published
2007
received
2007-07-17
revised
2007-09-23
accepted
2007-09-24
(unknown)
2007-12-08
References
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Document Type
Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv54p857kz
Identifiers
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