Chemical synthesis of dolichyl phosphates, their analogues and derivatives and application of these compounds in biochemical assays

• Authors: Leonid L Danilov , Tatyana N Druzhinina
• Languages of publication: EN

Abstracts

EN

Several methods for simple and efficient chemical synthesis of dolichyl phosphates and their analogues and derivatives are briefly summarized with a special emphasis on chemical modification of phosphoryl group and preparation of dolichyl phosphates labelled at the ω-end and at the γ-isoprene unit of the isoprene chain by fluorescent groups, 2-aminopyridine and 1-aminonaphtalene residues. Additionally, data on biochemical assays with application of the compounds mentioned above are presented.

Keywords

EN

fluorescent derivatives of Dol-P; FRET methodology; Dol-P-Man synthase; dolichyl phosphates

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2007
• Volume: 54
• Issue: 4
• Pages: 695-701

Dates

published

2007

received

2007-07-11

revised

2007-12-03

accepted

2007-12-07

(unknown)

2007-12-13

Contributors

author

Leonid L Danilov

• N.K. Kochetkov Laboratory of Carbohydrate Chemistry, N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

author

Tatyana N Druzhinina

• N.K. Kochetkov Laboratory of Carbohydrate Chemistry, N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

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