Bactericidal effect of photodynamic therapy against methicillin-resistant Staphylococcus aureus strain with the use of various porphyrin photosensitizers

• Authors: Mariusz Grinholc , Bozena Szramka , Katarzyna Olender , Alfreda Graczyk
• Languages of publication: EN

Abstracts

EN

Photodynamic therapy (PDT) is based on photosensitizers activated by light of appropriate wavelength. Their activation leads to generation of singlet oxygen and free radicals responsible for the cytotoxic effect. The aim of this project was to compare the bactericidal effect of PDT using different porphyrin photosensitizers against a methicillin-resistant Staphylococcus aureus strain. Exogenous sensitizers (protoporphyrin IX and newly synthesized derivative, protoporphyrin diarginate) induced a 3 log10-unit reduction in bacterial viable counts. With the use of endogenous, ALA-induced porphyrins, a 1.6 log10-unit reduction was obtained. The sensitizers tested executed their antibacterial activity with no essential change in the antibiotic resistance pattern of the studied strain.

Keywords

EN

photosensitizer; porphyrin; photodynamic therapy; MRSA

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2007
• Volume: 54
• Issue: 3
• Pages: 665-670

Dates

published

2007

received

2007-05-29

revised

2007-07-30

accepted

2007-08-17

(unknown)

2007-08-28

Contributors

author

Mariusz Grinholc

• Department of Biotechnology, Division of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Gdańsk, Gdańsk, Poland

author

Bozena Szramka

• Department of Biotechnology, Division of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Gdańsk, Gdańsk, Poland

author

Katarzyna Olender

• Institute of Optoelectronics, Military University of Technology, Warszawa, Poland

author

Alfreda Graczyk

• Institute of Optoelectronics, Military University of Technology, Warszawa, Poland

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