PL EN


Preferences help
enabled [disable] Abstract
Number of results
2007 | 54 | 3 | 665-670
Article title

Bactericidal effect of photodynamic therapy against methicillin-resistant Staphylococcus aureus strain with the use of various porphyrin photosensitizers

Content
Title variants
Languages of publication
EN
Abstracts
EN
Photodynamic therapy (PDT) is based on photosensitizers activated by light of appropriate wavelength. Their activation leads to generation of singlet oxygen and free radicals responsible for the cytotoxic effect. The aim of this project was to compare the bactericidal effect of PDT using different porphyrin photosensitizers against a methicillin-resistant Staphylococcus aureus strain. Exogenous sensitizers (protoporphyrin IX and newly synthesized derivative, protoporphyrin diarginate) induced a 3 log10-unit reduction in bacterial viable counts. With the use of endogenous, ALA-induced porphyrins, a 1.6 log10-unit reduction was obtained. The sensitizers tested executed their antibacterial activity with no essential change in the antibiotic resistance pattern of the studied strain.
Publisher

Year
Volume
54
Issue
3
Pages
665-670
Physical description
Dates
published
2007
received
2007-05-29
revised
2007-07-30
accepted
2007-08-17
(unknown)
2007-08-28
Contributors
  • Department of Biotechnology, Division of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Gdańsk, Gdańsk, Poland
  • Department of Biotechnology, Division of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Gdańsk, Gdańsk, Poland
  • Institute of Optoelectronics, Military University of Technology, Warszawa, Poland
  • Institute of Optoelectronics, Military University of Technology, Warszawa, Poland
References
  • Ashkenazi H, Malik Z, Harth Y, Nitzan Y (2003) FEMS Immunol Med Microbiol 35: 17-24.
  • Banfi S, Caruso E, Buccafurni L, Battini V, Zazzaron S, Barbieri P et al. (2006) J Photochem Photobiol B 85: 28-38.
  • Bertoloni G, Lauro FM, Cortella G, Merchat M (2000) Biochim Biophys Acta 1475: 169-174.
  • Bisland SK, Chien C, Wilson BC, Burch S (2006) Photochem Photobiol Sci 5: 31-38.
  • Chwilkowska A, Saczko J, Modrzycka T, Marcinkowska A, Malarska A, Bielewicz J, Patalas D, Banas T (2003) Acta Biochim Polon 50: 509-513.
  • Embleton ML, Nair SP, Cookson BD, Wilson M (2004) Microb Drug Resist 10: 92-97.
  • Embleton ML, Nair SP, Heywood W, Menon DC, Cookson BD, Wilson M (2005) Antimicrob Agents Chemother 49: 3690-3696.
  • Ferro S, Ricchelli F, Mancini G, Tognon G, Jori G (2006) J Photochem Photobiol B 83: 98-104.
  • Gad F, Zahra T, Hasan T, Hamblin MR (2004) Antimicrob Agents Chemother 48: 2173-2178.
  • Graczyk A, Konarski J (1994) Polish Patent, PL 165 249, B1.
  • Graczyk A, Konarski J (1995) United States Patent 5 451 599.
  • Graczyk A, Konarski J (1997) European Patent Specification EPO 539 960 B1.
  • Hryniewicz W, Sulikowska A, Szczypa K, Gniadkowski M, Skoczynska A (2005) Adv Microbiol 44: 175-192.
  • Jarraud S, Mougel Ch, Thioulouse J, Lina G, Meugnier H, Forey F et al. (2002) Infect Immun 70: 631-641.
  • Jori G, Brown SB (2004) Photochem Photobiol Sci 3: 403-405.
  • Konarski J (1990) CL5CO7D487122 no. 148 775.
  • Kurlenda J, Grinholc M, Jasek K, Wegrzyn G (2007) Med Sci Monit 13: MT13-18.
  • Lambrechts SAG, Demidova TN, Aalders MCG, Hasan T, Hamblin MR (2005) Photochem Photobiol Sci 4: 503-509.
  • Lasocki K, Szpakowska M, Grzybkowski J, Graczyk A (1999) Pharmacol Res 39: 181-184.
  • Maisch T, Bosl C, Szeimies RM, Lehn N, Abels C (2005) Antimicrob Agents Chemother 49: 1542-1552.
  • Malik Z, Ladan H, Nitzan Y, Smetana Z (1994) Photodynamic Therapy of Cancers (Jori G, Moan J, Star W.M. eds) Proc SPIE 2078: 305-312.
  • Nitzan Y, Salmon-Divon M, Shporen E, Malik Z (2004) Photochem Photobiol Sci 3: 430-435.
  • Orenstein A, Klein D, Kopolovic J, Winkler E, Malik Z, Keller N et al. (1997) FEMS Immunol Med Microbiol 19: 307-314.
  • Padzik-Graczyk A, Konarski J, Sobczynska J (1993) Polish Patent, PL 165 248, B1.
  • Romanova NA, Brovko LY, Moore L, Pometun E, Savitsky AP, Ugarova NN et al. (2003) Appl Environ Microbiol 69: 6393-6398.
  • Shawar R, Cooper BH (1990) Photochem Photobiol 52: 825-830.
  • Szpakowska M, Lasocki K, Grzybowski J, Graczyk A (2001) Pharmacol Res 44: 243-247.
  • Szurko A, Kramer-Marek G, Wide M, Ratuszna A, Habdas J, Kus P (2003) Acta Biochim Polon 50: 1165-1174.
  • Tegos GP, Hamblin MR (2006) Antimicrob Agents Chemother 50: 196-203.
  • Zeina B, Greenman J, Purcell WM, Das B (2001) Br J Dermatol 144: 274-278.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv54p665kz
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.