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2007 | 54 | 1 | 51-54

Article title

The genetic code - 40 years on

Content

Title variants

Languages of publication

EN

Abstracts

EN
The genetic code discovered 40 years ago, consists of 64 triplets (codons) of nucleotides. The genetic code is almost universal. The same codons are assigned to the same amino acids and to the same START and STOP signals in the vast majority of genes in animals, plants, and microorganisms. Each codon encodes for one of the 20 amino acids used in the synthesis of proteins. That produces some redundancy in the code and most of the amino acids being encoded by more than one codon. The two cases have been found where selenocysteine or pyrrolysine, that are not one of the standard 20 is inserted by a tRNA into the growing polypeptide.

Year

Volume

54

Issue

1

Pages

51-54

Physical description

Dates

published
2007
received
2007-02-20
revised
2007-03-05
accepted
2007-03-09
(unknown)
2007-03-20

Contributors

  • Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Poznań, Poland
  • Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Poznań, Poland

References

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  • Beier H, Grimm M (2001) Misreading of termination codons in eukaryotes by natural nonsense suppressor tRNAs. Nucleic Acids Res 29: 4767-4782.
  • Beuning PJ, Musier-Forsyth K (1999) Transfer RNA recognition by aminoacyl-tRNA synthetases. Biopolymers 52: 1-28.
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  • Fagegaltier D, Hubert N, Yamada K, Mizutani T, Carbon P, Krol A (2000) Characterization of mSelB, a novel mammalian elongation factor for selenoprotein translation. EMBO J 19: 4796-4805.
  • Gesteland RF, Atkins JF (1996) Recoding: dynamic reprogramming of translation. Annu Rev Biochem 65: 741-768.
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  • Longstaff DG, Blight SK, Zhang L, Green-Church KB, Krzycki JA (2007) In vivo contextual requirements for UAG translation as pyrrolysine. Mol Microbiol 63: 229-241.
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  • Srinivasan G, James CM, Krzycki JA (2002) Pyrrolysine encoded by UAG in Archaea: charging of a UAG-decoding specialized tRNA. Science 296: 1459-1462.
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  • Travers A (2006) The evolution of the genetic code revisited. Orig Life Evol Biosph 36: 549-555.
  • Turner BM (2007) Defining an epigenetic code. Nat Cell Biol 9: 2-6.
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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.bwnjournal-article-abpv54p51kz
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