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2007 | 54 | 1 | 51-54
Article title

The genetic code - 40 years on

Content
Title variants
Languages of publication
EN
Abstracts
EN
The genetic code discovered 40 years ago, consists of 64 triplets (codons) of nucleotides. The genetic code is almost universal. The same codons are assigned to the same amino acids and to the same START and STOP signals in the vast majority of genes in animals, plants, and microorganisms. Each codon encodes for one of the 20 amino acids used in the synthesis of proteins. That produces some redundancy in the code and most of the amino acids being encoded by more than one codon. The two cases have been found where selenocysteine or pyrrolysine, that are not one of the standard 20 is inserted by a tRNA into the growing polypeptide.
Year
Volume
54
Issue
1
Pages
51-54
Physical description
Dates
published
2007
received
2007-02-20
revised
2007-03-05
accepted
2007-03-09
(unknown)
2007-03-20
References
  • Ambrogelly A, Palioura S, Soll D (2007) Natural expansion of the genetic code. Nat Chem Biol 3: 29-35.
  • Beier H, Grimm M (2001) Misreading of termination codons in eukaryotes by natural nonsense suppressor tRNAs. Nucleic Acids Res 29: 4767-4782.
  • Beuning PJ, Musier-Forsyth K (1999) Transfer RNA recognition by aminoacyl-tRNA synthetases. Biopolymers 52: 1-28.
  • Cornish VW, Mendel D, Schultz PG (1995) Probing protein structure and function with an expanded genetic code. Angew Chem Int Ed Engl 34: 621-633.
  • Fagegaltier D, Hubert N, Yamada K, Mizutani T, Carbon P, Krol A (2000) Characterization of mSelB, a novel mammalian elongation factor for selenoprotein translation. EMBO J 19: 4796-4805.
  • Gesteland RF, Atkins JF (1996) Recoding: dynamic reprogramming of translation. Annu Rev Biochem 65: 741-768.
  • Ibba M, Söll D (2001) The renaissance of aminoacyl-tRNA synthesis. EMBO Rep 2: 382-387.
  • Knight RD, Freeland SJ, Landweber LF (2001) Rewiring the keyboard: evolvability of the genetic code. Nat Rev Genet 2: 49-58.
  • Longstaff DG, Blight SK, Zhang L, Green-Church KB, Krzycki JA (2007) In vivo contextual requirements for UAG translation as pyrrolysine. Mol Microbiol 63: 229-241.
  • Miranda I, Silva R, Santos MA (2006) Evolution of genetic code in yeast. Yeast 23: 203-213.
  • Mix H, Lobanov AV, Gladyshev VN (2007) SECIS elements in the coding regions of selenoprotein transcripts are functional in higher eukaryotes. Nucleic Acids Res 35: 414-423.
  • Nirenberg M (2004) Historical review: deciphering the genetic code - a personal account. Trends Biochem Sci 29: 46-54.
  • Nirenberg MW, Matthae JH, Jones OW (1962) An intermediate in the biosynthesis of polyphenylalanine directed by synthetic template RNA. Proc Natl Acad Sci USA 48: 104-109.
  • Nirenberg M, Caskey T, Marshall R, Brimacombe R, Kellogg D, Doctor B, Hatfield D, Levin J, Rottman F, Pestka S, Wilcox M, Anderson F (1966) The RNA code and protein synthesis. Cold Spring Harb Symp Quant Biol 31: 11-24.
  • Rich A (2004) The excitement of discovery. Annu Rev Biochem 73: 1-37.
  • Srinivasan G, James CM, Krzycki JA (2002) Pyrrolysine encoded by UAG in Archaea: charging of a UAG-decoding specialized tRNA. Science 296: 1459-1462.
  • Szathmary E (1999) The origin of the genetic code. Trends Genet 15: 223-229.
  • Travers A (2006) The evolution of the genetic code revisited. Orig Life Evol Biosph 36: 549-555.
  • Turner BM (2007) Defining an epigenetic code. Nat Cell Biol 9: 2-6.
  • Watson JD, Crick FHC (1953) Molecular structure of nucleic acids. A structure for deoxyribose nucleic acid. Nature 171: 737-738.
  • Woese CR (2001) Translation: in retrospect and prospect, RNA 7: 1055-1067.
Document Type
Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv54p51kz
Identifiers
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