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2007 | 54 | 2 | 407-411
Article title

Menadione effect on l-cysteine desulfuration in U373 cells

Content
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EN
Abstracts
EN
The non-cytotoxic concentration (20 µM) of menadione (2-methyl-1,4-naphthoquinone), after 1 h of incubation, leads to loss of the activity of rhodanese by 33%, 3-mercaptopyruvate sulfurtransferase by 20%, as well as the level of sulfane sulfur by about 23% and glutathione by 12%, in the culture of U373 cells, in comparison with the control culture. Reactive oxygen species generated by menadione oxidize sulfhydryl groups in active centers of the investigated enzymes, inhibiting them and saving cysteine for glutathione synthesis. A decreased sulfane sulfur level can be correlated with an oxidative stress.
Publisher

Year
Volume
54
Issue
2
Pages
407-411
Physical description
Dates
published
2007
received
2007-03-13
revised
2007-03-30
accepted
2007-04-16
(unknown)
2007-05-23
Contributors
author
  • Chair of Medical Biochemistry, Jagiellonian University Medical College, Kraków, Poland
  • Chair of Medical Biochemistry, Jagiellonian University Medical College, Kraków, Poland
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv54p407kz
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