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2007 | 54 | 2 | 349-355
Article title

Gamijeonssibaekchulsan regulates mast cell-mediated anaphylactic reaction

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EN
Abstracts
EN
Gamijeonssibaekchulsan (GJBS) is a typical Oriental medicine prescription which has been used in Korea for the treatment of allergic diseases and the development of physical strength. However, as yet there is no clear explanation of how GJBS affects the anaphylactic reaction and the immune function. In the present study murine models and MOLT-4 cells, a T cell line, were used to investigate these effects. Compound 48/80-induced systemic anaphylactic shock and ear swelling response were firstly analyzed. We also assayed histamine release and passive cutaneous anaphylaxis (PCA) in mice and cytokine productions in MOLT-4 cells. GJBS significantly inhibits compound 48/80-induced systemic anaphylactic shock and ear swelling response. GJBS also inhibits histamine release from rat peritoneal mast cells induced by compound 48/80. PCA activated by anti-dinitrophenyl immunoglobulin E is attenuated by GJBS. However, GJBS dose not affect the production of interferon-γ, interleukin (IL)-2, and IL-4 in MOLT-4 cells. These results indicate that GJBS has a potential regulatory effect on allergic reactions that are mediated by mast cells.
Year
Volume
54
Issue
2
Pages
349-355
Physical description
Dates
published
2007
received
2007-01-10
revised
2007-05-08
accepted
2007-05-22
(unknown)
2007-06-04
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Document Type
Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv54p349kz
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