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2007 | 54 | 1 | 1-9
Article title

Melatonin and its metabolites: new findings regarding their production and their radical scavenging actions

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Abstracts
EN
This review summarizes some of the recent findings concerning the long-held tenet that the enzyme, N-acetyltransferase, which is involved in the production of N-acetylserotonin, the immediate precursor of melatonin, may in fact not always control the quantity of melatonin generated. New evidence from several different laboratories indicates that hydroxyindole-O-methyltransferase, which O-methylates N-acetylserotonin to melatonin may be rate-limiting in some cases. Also, the review makes the point that melatonin's actions are uncommonly widespread in organs due to the fact that it works via membrane receptors, nuclear receptors/binding sites and receptor-independent mechanisms, i.e., the direct scavenging of free radicals. Finally, the review briefly summarizes the actions of melatonin and its metabolites in the detoxification of oxygen and nitrogen-based free radicals and related non-radical products. Via these multiple processes, melatonin is capable of influencing the metabolism of every cell in the organism.
Year
Volume
54
Issue
1
Pages
1-9
Physical description
Dates
published
2007
received
2007-02-16
accepted
2007-02-27
(unknown)
2007-03-09
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bwmeta1.element.bwnjournal-article-abpv54p1kz
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