Hypothesis: cell volume limits cell divisions

• Authors: Tomasz Biliński , Grzegorz Bartosz
• Languages of publication: EN

Abstracts

EN

Mammalian somatic cells and also cells of the yeast Saccharomyces cerevisiae are capable of undergoing a limited number of divisions. Reaching the division limit is referred to, apparently not very fortunately, as replicative aging. A common feature of S. cerevisiae cells and fibroblasts approaching the limit of cell divisions in vitro is attaining giant volumes. In yeast cells this phenomenon is an inevitable consequence of budding so it is not causally related to aging. Therefore, reaching a critically large cell volume may underlie the limit of cell divisions. A similar phenomenon may limit the number of cell divisions of cultured mammalian cells. The term replicative (generative) aging may be therefore illegitimate.

Keywords

EN

replicative aging; Saccharomyces cerevisiae; cell volume; yeast

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2006
• Volume: 53
• Issue: 4
• Pages: 833-835

Dates

published

2006

received

2006-06-10

revised

2006-09-25

accepted

2006-10-09

(unknown)

2006-11-14

Contributors

author

Tomasz Biliński

• Department of Biochemistry and Cell Biology, University of Rzeszów, Rzeszów, Poland

author

Grzegorz Bartosz

• Department of Biochemistry and Cell Biology, University of Rzeszów, Rzeszów, Poland

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