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2006 | 53 | 4 | 833-835
Article title

Hypothesis: cell volume limits cell divisions

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EN
Abstracts
EN
Mammalian somatic cells and also cells of the yeast Saccharomyces cerevisiae are capable of undergoing a limited number of divisions. Reaching the division limit is referred to, apparently not very fortunately, as replicative aging. A common feature of S. cerevisiae cells and fibroblasts approaching the limit of cell divisions in vitro is attaining giant volumes. In yeast cells this phenomenon is an inevitable consequence of budding so it is not causally related to aging. Therefore, reaching a critically large cell volume may underlie the limit of cell divisions. A similar phenomenon may limit the number of cell divisions of cultured mammalian cells. The term replicative (generative) aging may be therefore illegitimate.
Publisher

Year
Volume
53
Issue
4
Pages
833-835
Physical description
Dates
published
2006
received
2006-06-10
revised
2006-09-25
accepted
2006-10-09
(unknown)
2006-11-14
Contributors
  • Department of Biochemistry and Cell Biology, University of Rzeszów, Rzeszów, Poland
  • Department of Biochemistry and Cell Biology, University of Rzeszów, Rzeszów, Poland
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv53p833kz
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