Synthesis, antimicrobial activity and structural studies of low molecular mass lysine dendrimers

• Authors: Jolanta Janiszewska , Zofia Urbańczyk-Lipkowska
• Languages of publication: EN

Abstracts

EN

Four low molecular mass lysine dendrimers were synthesized by Boc chemistry in solution (155 and 169) and Fmoc chemistry on solid support (P2 and P13). The structure and fragmentation mode of the above dendrimers was investigated in gas phase by the LSI-MS and ESI-MS techniques. 1H and 13C NMR analysis in solution (d6-DMSO) allowed to confirm the correct structure. Antimicrobial activities of the dendrimers against Staphylococcus aureus, Escherichia coli and Candida albicans confirmed our hypothesis that the dendrimer structure can be used for construction of molecules interacting with biological membranes.

Keywords

EN

basic dendrimers; nuclear magnetic resonance (NMR).; natural antibacterial peptides; mass spectrometry (MS); antibiotic resistance

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2006
• Volume: 53
• Issue: 1
• Pages: 77-82

Dates

published

2006

revised

2005-01-19

received

2005-11-06

accepted

2006-02-16

(unknown)

2006-02-23

Contributors

author

Jolanta Janiszewska

• Industrial Chemistry Research Institute, Warszawa, Poland

author

Zofia Urbańczyk-Lipkowska

• Institute of Organic Chemistry PAS, Warszawa, Poland

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