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2006 | 53 | 1 | 77-82
Article title

Synthesis, antimicrobial activity and structural studies of low molecular mass lysine dendrimers

Content
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Languages of publication
EN
Abstracts
EN
Four low molecular mass lysine dendrimers were synthesized by Boc chemistry in solution (155 and 169) and Fmoc chemistry on solid support (P2 and P13). The structure and fragmentation mode of the above dendrimers was investigated in gas phase by the LSI-MS and ESI-MS techniques. 1H and 13C NMR analysis in solution (d6-DMSO) allowed to confirm the correct structure. Antimicrobial activities of the dendrimers against Staphylococcus aureus, Escherichia coli and Candida albicans confirmed our hypothesis that the dendrimer structure can be used for construction of molecules interacting with biological membranes.
Publisher

Year
Volume
53
Issue
1
Pages
77-82
Physical description
Dates
published
2006
revised
2005-01-19
received
2005-11-06
accepted
2006-02-16
(unknown)
2006-02-23
Contributors
  • Industrial Chemistry Research Institute, Warszawa, Poland
  • Institute of Organic Chemistry PAS, Warszawa, Poland
References
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  • Frechet JM, Tomalia DA (2002) Dendrimers and other dendritic polymers. Wiley Series in Polymer Science.
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  • Janiszewska J, Swieton J, Lipkowski AW, Urbanczyk-Lipkowska Z (2003) Low molecular mass peptide dendrimers that express antimicrobial properties. Bioorg Med Chem Lett 13: 3711-3713.
  • Kupper TS, Fuhlbrigge RC (2004) Immune surveillance in the skin: mechanisms and clinical consequences. Nat Rev Immunol 4: 211-222.
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  • Papo N, Shai Y (2003) Exploring peptide membrane interaction using surface plasmon resonance: differentiation between pore formation versus membrane disruption by lytic peptides. Biochemistry 42: 458-466.
  • Powers JPS, Hancock RE (2003) The relations between peptide structure and antibacterial activity. Peptides 24: 1681-1691.
  • Reddy KVR, Yedery RD, Aranha C (2004) Antimicrobial peptides: premises and promises. Int J Antimicrob Agents 24: 536-547.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv53p77kz
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