Relationship between the replicative age and cell volume in Saccharomyces cerevisiae

• Authors: Renata Zadrag , Magdalena Kwolek-Mirek , Grzegorz Bartosz , Tomasz Bilinski
• Languages of publication: EN

Abstracts

EN

Reaching the limit of cell divisions, a phenomenon referred to as replicative aging, of the yeast Saccharomyces cerevisiae involves a progressive increase in the cell volume. However, the exact relationship between the number of cell divisions accomplished (replicative age), the potential for further divisions and yeast cell volume has not been investigated thoroughly. In this study an increase of the yeast cell volume was achieved by treatment with pheromone α for up to 18 h. Plotting the number of cell divisions (replicative life span) of the pheromone-treated cells as a function of the cell volume attained during the treatment showed an inverse linear relationship. An analogous inverse relationship between the initial cell volume and replicative life span was found for the progeny of the pheromone-treated yeast. This phenomenon indicates that attaining an excessive volume may be a factor contributing to the limitation of cellular divisions of yeast cells.

Keywords

EN

replicative aging; Saccharomyces cerevisiae; cell volume; yeast

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2006
• Volume: 53
• Issue: 4
• Pages: 747-751

Dates

published

2006

received

2006-06-10

revised

2006-09-25

accepted

2006-10-09

(unknown)

2006-11-14

Contributors

author

Renata Zadrag

• Department of Biochemistry and Cell Biology, University of Rzeszów, Rzeszów, Poland

author

Magdalena Kwolek-Mirek

• Department of Biochemistry and Cell Biology, University of Rzeszów, Rzeszów, Poland

author

Grzegorz Bartosz

• Department of Biochemistry and Cell Biology, University of Rzeszów, Rzeszów, Poland

author

Tomasz Bilinski

• Department of Biochemistry and Cell Biology, University of Rzeszów, Rzeszów, Poland

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