PL EN


Preferences help
enabled [disable] Abstract
Number of results
2006 | 53 | 4 | 747-751
Article title

Relationship between the replicative age and cell volume in Saccharomyces cerevisiae

Content
Title variants
Languages of publication
EN
Abstracts
EN
Reaching the limit of cell divisions, a phenomenon referred to as replicative aging, of the yeast Saccharomyces cerevisiae involves a progressive increase in the cell volume. However, the exact relationship between the number of cell divisions accomplished (replicative age), the potential for further divisions and yeast cell volume has not been investigated thoroughly. In this study an increase of the yeast cell volume was achieved by treatment with pheromone α for up to 18 h. Plotting the number of cell divisions (replicative life span) of the pheromone-treated cells as a function of the cell volume attained during the treatment showed an inverse linear relationship. An analogous inverse relationship between the initial cell volume and replicative life span was found for the progeny of the pheromone-treated yeast. This phenomenon indicates that attaining an excessive volume may be a factor contributing to the limitation of cellular divisions of yeast cells.
Publisher

Year
Volume
53
Issue
4
Pages
747-751
Physical description
Dates
published
2006
received
2006-06-10
revised
2006-09-25
accepted
2006-10-09
(unknown)
2006-11-14
Contributors
author
  • Department of Biochemistry and Cell Biology, University of Rzeszów, Rzeszów, Poland
  • Department of Biochemistry and Cell Biology, University of Rzeszów, Rzeszów, Poland
  • Department of Biochemistry and Cell Biology, University of Rzeszów, Rzeszów, Poland
  • Department of Biochemistry and Cell Biology, University of Rzeszów, Rzeszów, Poland
References
  • Abramczyk O, Zien P, Zielinski R, Pilecki M, Hellman U, Szyszka R (2003) The protein kinase 60S is a free catalytic CK2α' subunit and forms an inactive complex with superoxide dismutase SOD1. Biochem Biophys Res Commun 307: 31-40.
  • Angello JC, Pendergrass WR, Norwood TH, Prothero J (1987) Proliferative potential of human fibroblasts: an inverse dependence on cell size. J Cell Physiol 132: 125-130.
  • Angello JC, Pendergrass WR, Norwood TH, Prothero J (1989) Cell enlargement: one possible mechanism underlying cellular senescence. J Cell Physiol 140: 288-294.
  • Bilinski T, Lukaszkiewicz J, Sledziewski A (1978) Demonstration of anaerobic catalase synthesis in the cz1 mutant of Saccharomyces cerevisiae. Biochem Biophys Res Commun 83: 1225-1233.
  • Bilinski T, Krawiec Z, Liczmanski A, Litwinska J (1985) Is hydroxyl radical generated by the Fenton reaction in vivo? Biochem Biophys Res Commun 130: 533-539.
  • Bitterman KJ, Medvedik O, Sinclair DA (2003) Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin. Microbiol Mol Biol Rev 67: 376-399.
  • Egilmez NK, Jazwinski SM (1989) Evidence for the involvement of a cytoplasmic factor in the aging of the yeast Saccharomyces cerevisiae. J Bacteriol 171: 37-42.
  • Gershon H, Gershon D (2000) The budding yeast, Saccharomyces cerevisiae, as a model for aging research: a critical review. Mech Ageing Dev 120: 1-22.
  • Gillespie CS, Proctor CJ, Boys RJ, Shanley DP, Wilkinson DJ, Kirkwood TB (2004) A mathematical model of ageing in yeast. J Theor Biol 229: 189-196.
  • Guarente L (2000) Sir2 links chromatin silencing, metabolism, and aging. Genes Dev 14: 1021-1026.
  • Jazwinski SM, Egilmez NK, Chen JB (1989) Replication control and cellular life span. Exp Gerontol 24: 423-436.
  • Kennedy BK, Austriaco NR Jr, Guarente L (1994) Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span. J Cell Biol 127: 1985-1993.
  • Kim S, Kirchman PA, Benguria A, Jazwinski SM (1999) Experimentation with the yeast model. In Methods in Aging Research (Yu BP, ed) vol 1, pp 191-213. CRC Press, Boca Raton, Boston, London, New York, Washington, DC.
  • Mortimer RK, Johnston JR (1959) Life span of individual yeast cells. Nature 183: 1751-1752.
  • Sinclair DA (2002) Paradigms and pitfalls of yeast longevity research. Mech Ageing Dev 123: 857-867.
  • Sinclair DA, Mills K, Guarente L (1998) Molecular mechanisms of yeast aging. Trends Biochem Sci 23: 131-134.
  • Sumikawa E, Matsumoto Y, Sakemura R, Fujii M, Ayusawa D (2005) Prolonged unbalanced growth induces cellular senescence markers linked with mechano transduction in normal and tumor cells. Biochem Biophys Res Commun 335: 558-565.
  • Wawryn J, Krzepilko A, Myszka A, Bilinski T (1999) Deficiency in superoxide dismutases shortens life span of yeast cells. Acta Biochim Polon 46: 249-253.
  • Wojnar L, Kurzydlowski KJ, Szala J (2002) Praktyka analizy obrazu. Polskie Towarzystwo Stereologiczne, Kraków.
  • Zadrag R, Bartosz G, Bilinski T (2005) Replicative aging of the yeast does not require DNA replication. Biochem Biophys Res Commun 333: 138-141.
  • Zielinski R, Pilecki M, Kubinski K, Zien P, Hellman U, Szyszka R (2002) Inhibition of yeast ribosomal stalk phosphorylation by Cu-Zn superoxide dismutase. Biochem Biophys Res Commun 296: 1310-1316.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv53p747kz
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.