Chelating ability of proctolin tetrazole analogue

• Authors: Elżbieta Łodyga-Chruścińska , Daniele Sanna , Giovanni Micera , Longin Chruściński , Jadwiga Olejnik , Ronald J Nachman , Janusz Zabrocki
• Languages of publication: EN

Abstracts

EN

The aim of the investigation was to establish the chelating ability of a new proctolin analogue of the sequence Arg-Tyr-LeuΨ[CN4]Ala-Thr towards copper(II) ions. The insertion of the tetrazole moiety into the peptide sequence has considerably changed the coordination ability of the ligand. Potentiometric and spectroscopic (UV-Vis, CD, EPR) results indicate that the incorporation of 1,5-disubstituted tetrazole ring favours the formation of a stable complex form of CuH-1L. This 4N coordination type complex is the dominant species in the physiological pH range. The tetrazole moiety provides one of these nitrogens. The data indicate that Cu(II) ions are strongly trapped inside the peptide backbone. These findings suggest that Cu(II) can hold peptide chains in a bent conformation. This bent conformation may be essential for bioactivity of the tetrazole peptides.

Keywords

EN

metallopeptides; metal complexes; proctolin; tetrazole peptide analogue

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2006
• Volume: 53
• Issue: 1
• Pages: 65-72

Dates

published

2006

received

2005-11-06

revised

2006-01-25

accepted

2006-02-16

(unknown)

2006-02-23

Contributors

author

Elżbieta Łodyga-Chruścińska

• Institute of General Food Chemistry, Technical University of Łódź, Łódź, Poland

author

Daniele Sanna

• Istituto C.N.R. Chim. Biomolecolare, Sassari, Italy

author

Giovanni Micera

• Department of Chemistry, University of Sassari, Sassari, Italy

author

Longin Chruściński

• Faculty of Process and Environmental Engineering, Technical University of Łódź, Łódź, Poland

author

Jadwiga Olejnik

• Institute of Organic Chemistry, Technical University of Łódź, Łódź, Poland

author

Ronald J Nachman

• Areawide Pest Management Unit, Southern Plains Agricultural Research Center, U.S. Department of Agriculture, College Station, USA,

author

Janusz Zabrocki

• Institute of Organic Chemistry, Technical University of Łódź, Łódź, Poland

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