A novel polypeptide from Cervus nippon Temminck proliferation of epidermal cells and NIH3T3 cell line

• Authors: Shu-Wen Guan , Leng-Xin Duan , Yuan-Yuan Li , Ben-Xiang Wang , Qiu-Li Zhou
• Languages of publication: EN

Abstracts

EN

A novel polypeptide, velvet antler polypeptide (VAPPs), having a stimulary effect on proliferation of some cell was isolated from the velvet antler of sika deer (Cervus nippon Temminck). This polypeptide consists of a single chain of 32 amino-acid residues VLSAT DKTNV LAAWG KVGGN APAFG AEALE RM. VAPPs showed marked stimulary effect on rat epidermal cells and NIH3T3 cell line (dose range from 10-40 mg·L-1 and 5-80 mg·L-1, respectively).

Keywords

EN

polypeptide; velvet antler; promoting cell proliferation

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2006
• Volume: 53
• Issue: 2
• Pages: 395-397

Dates

published

2006

received

2005-10-12

revised

2006-01-19

accepted

2006-02-23

(unknown)

2006-06-12

Contributors

author

Shu-Wen Guan

• Laboratory of Biological Macromolecule, College of Life Science, Changchun, China

author

Leng-Xin Duan

• Institute of Frontier Medical, Jilin University, Changchun, China

author

Yuan-Yuan Li

• Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, Jilin University, Changchun, China

author

Ben-Xiang Wang

• Jilin Tianyao Science and Technology Co. Ltd, Changchun, China

author

Qiu-Li Zhou

• Institute of Frontier Medical, Jilin University, Changchun, China

References

• Baden HP, Kubilus J (1983) The growth and differentiation of cultured newborn rat keratinocytes. J Invest Dermatol 80: 124-130.
• Garcia RL, Sadighi M, Francis SM, Suttie JM, Fleming JS (1997) Expression of neurotrophin-3 in the growing velvet antler of the red deer Cervus elaphus. J Mol Endocrinol 19: 173-182.
• Goransson U, Luijendijk T, Johansson S, Bohlin L, Claeson P (1999) Seven novel macrocyclic polypeptides from Viola arvensis. J Nat Prod 62: 283-286.
• Kato Y, Hiraki Y, Inoue H (1983) Differential and synergistic actions of somatomedin-like growth factors, fibroblast growth factor and epidermal growth factor in rabbit costal chondrocytes. Eur J Biochem 129: 685-690.
• Ko KM, Yip TT, Tsao SW, Kong YC, Fennessy PF, Belew MC, Porath J (1986) Epidermal growth factor from deer (Cervus elaphus) submaxillary gland and velvet antler. Gen Comp Endocrinol 63: 431-440.
• Suttie JM, Gluckman PD, Butler JH, Fennessy PF (1985) Insulin-like growth factor 1 (IGF-1) antler-stimulating hormone. Endocrinology 116: 846-848.
• Weng L, Zhou QL, Ikejima T, Wang BX (2001) A new polypeptide promoting epidermal cells and chondrocytes proliferation from Cervus elaphus Linnaeus. Acta Pharm Sin 36: 913-916.
• Weng L, Zhou QL, Ikejima T, Wang BX (2002) A novel polypeptide from Cervus elaphus Linnaeus. Chin Chem Lett 13: 147-150.
• Zhou QL, Guo YJ, Wang LJ, Wang Y, Liu YQ, Wang Y, Wang BX (1999) Velvet antler polypeptides promoted proliferation of chondrocytes and osteoblast precursors and fracture healing. Acta Pharmacol Sin 20: 279-282.