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2006 | 53 | 2 | 395-397
Article title

A novel polypeptide from Cervus nippon Temminck proliferation of epidermal cells and NIH3T3 cell line

Content
Title variants
Languages of publication
EN
Abstracts
EN
A novel polypeptide, velvet antler polypeptide (VAPPs), having a stimulary effect on proliferation of some cell was isolated from the velvet antler of sika deer (Cervus nippon Temminck). This polypeptide consists of a single chain of 32 amino-acid residues VLSAT DKTNV LAAWG KVGGN APAFG AEALE RM. VAPPs showed marked stimulary effect on rat epidermal cells and NIH3T3 cell line (dose range from 10-40 mg·L-1 and 5-80 mg·L-1, respectively).
Publisher

Year
Volume
53
Issue
2
Pages
395-397
Physical description
Dates
published
2006
received
2005-10-12
revised
2006-01-19
accepted
2006-02-23
(unknown)
2006-06-12
Contributors
author
  • Laboratory of Biological Macromolecule, College of Life Science, Changchun, China
author
  • Institute of Frontier Medical, Jilin University, Changchun, China
author
  • Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, Jilin University, Changchun, China
  • Jilin Tianyao Science and Technology Co. Ltd, Changchun, China
author
  • Institute of Frontier Medical, Jilin University, Changchun, China
References
  • Baden HP, Kubilus J (1983) The growth and differentiation of cultured newborn rat keratinocytes. J Invest Dermatol 80: 124-130.
  • Garcia RL, Sadighi M, Francis SM, Suttie JM, Fleming JS (1997) Expression of neurotrophin-3 in the growing velvet antler of the red deer Cervus elaphus. J Mol Endocrinol 19: 173-182.
  • Goransson U, Luijendijk T, Johansson S, Bohlin L, Claeson P (1999) Seven novel macrocyclic polypeptides from Viola arvensis. J Nat Prod 62: 283-286.
  • Kato Y, Hiraki Y, Inoue H (1983) Differential and synergistic actions of somatomedin-like growth factors, fibroblast growth factor and epidermal growth factor in rabbit costal chondrocytes. Eur J Biochem 129: 685-690.
  • Ko KM, Yip TT, Tsao SW, Kong YC, Fennessy PF, Belew MC, Porath J (1986) Epidermal growth factor from deer (Cervus elaphus) submaxillary gland and velvet antler. Gen Comp Endocrinol 63: 431-440.
  • Suttie JM, Gluckman PD, Butler JH, Fennessy PF (1985) Insulin-like growth factor 1 (IGF-1) antler-stimulating hormone. Endocrinology 116: 846-848.
  • Weng L, Zhou QL, Ikejima T, Wang BX (2001) A new polypeptide promoting epidermal cells and chondrocytes proliferation from Cervus elaphus Linnaeus. Acta Pharm Sin 36: 913-916.
  • Weng L, Zhou QL, Ikejima T, Wang BX (2002) A novel polypeptide from Cervus elaphus Linnaeus. Chin Chem Lett 13: 147-150.
  • Zhou QL, Guo YJ, Wang LJ, Wang Y, Liu YQ, Wang Y, Wang BX (1999) Velvet antler polypeptides promoted proliferation of chondrocytes and osteoblast precursors and fracture healing. Acta Pharmacol Sin 20: 279-282.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv53p395kz
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