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2006 | 53 | 2 | 245-256
Article title

Mammalian DNA methyltransferases

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Abstracts
EN
DNA methylation is an epigenetic process affecting gene expression and chromatin organization. It can heritably silence or activate transcription of genes without any change in their nucleotide sequences, and for a long time was not recognized as an important regulatory mechanism. However, during the recent years it has been shown that improper methylation, especially hypermethylation of promoter regions, is observed in nearly all steps of tumorigenesis. Aberrant methylation is also the cause of several major pathologies including developmental disorders involving chromosome instabilities and mental retardation. A great progress has been made in our understanding of the enzymatic machinery involved in establishing and maintaining methylation patterns. This allowed for the development of new diagnostic tools and epigenetic treatment therapies. The new approaches hold a great potential; several inhibitors of DNA methyltransferases have already shown very promising therapeutic effects.
Publisher

Year
Volume
53
Issue
2
Pages
245-256
Physical description
Dates
published
2006
received
2005-12-28
revised
2006-02-17
accepted
2006-02-24
(unknown)
2006-04-03
Contributors
  • Bioinformatics Department, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland
  • Plant Molecular Biology Department, Warsaw University, Warszawa, Poland
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bwmeta1.element.bwnjournal-article-abpv53p245kz
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