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2006 | 53 | 1 | 227-232
Article title

Conformational properties of N-acetyl-N-methyl-α,β-dehydroalanine N'-methylamide

Content
Title variants
Languages of publication
EN
Abstracts
EN
The conformational properties of Ac-Δ(Me)Ala-NHMe (N-acetyl-N-methyl-α,β-dehydroalanine N'-methylamide), as the simplest model of N-methyl-α,β-dehydroamino acids, was examined with theoretical methods and in comparison with Ac-ΔAla-NHMe and Ac-ΔAla-NMe2. The N-terminal amide of the Δ(Me)Ala residue easily adopts the configuration cis and the torsion angles φ, ψ are highly flexible. The Δ(Me)Ala residue is a conformational flexibilizer as compared to the parent ΔAla, which is a conformational stiffener. This seems to be the reason why Δ(Me)Ala is found in small natural cyclic peptides, where it ensures the conformational flexibility necessary for biological action.
Year
Volume
53
Issue
1
Pages
227-232
Physical description
Dates
published
2006
received
2005-11-06
revised
2006-02-12
accepted
2006-03-02
(unknown)
2006-03-09
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Document Type
Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv53p227kz
Identifiers
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