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2006 | 53 | 1 | 179-188
Article title

Up-regulation of human PNPase mRNA by β-interferon has no effect on protein level in melanoma cell lines

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EN
Abstracts
EN
Human mitochondrial polynucleotide phosphorylase (hPNPase) is an exoribonuclease localized in mitochondria. The exact physiological function of this enzyme is unknown. Recent studies have revealed the existence of a relationship between induction of hPNPase mRNA and both cellular senescence and growth arrest of melanoma cells following β-interferon treatment. The aim of this study was to verify whether the augmented hPNPase mRNA level results in increase of the protein level. In several cell lines established from five metastatic melanoma patients we did not find any such correlation. However, an elevated level of hPNPase protein was observed in interferon-induced HeLa and Jurkat cells. This increase was correlated with a slight shortening of poly(A) tails of mitochondrial ND3 transcript.
Year
Volume
53
Issue
1
Pages
179-188
Physical description
Dates
published
2006
received
2005-12-08
accepted
2006-02-16
revised
2006-02-16
(unknown)
2006-02-26
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Document Type
Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv53p179kz
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