PL EN


Preferences help
enabled [disable] Abstract
Number of results
2005 | 52 | 4 | 943-946
Article title

Isolation and expression pattern of RGS21 gene, a novel RGS member

Content
Title variants
Languages of publication
EN
Abstracts
EN
Regulators of G-protein signaling (RGS) proteins are known for the RGS domain that is composed of a conserved stretch of 120 amino acids, which binds directly to activated G-protein α subunits and acts as a GTPase-activating protein (GAP), leading to their deactivation and termination of downstream signals. In this study, a novel human RGS cDNA (RGS21), 1795 bp long and encoding a 152-amino acid polypeptide, was isolated by large-scale sequencing analysis of a human fetal brain cDNA library. Unlike other RGS family members, RGS21 gene has no additional domain/motif and may represent the smallest known member of RGS family. It may belong to the B/R4 subfamily, which suggests that it may serve exclusively as a negative regulator of αi/o family members and/or αq/11. PCR analysis showed that RGS21 mRNA was expressed ubiquitously in the 16 tissues examined, implying general physiological roles.
Year
Volume
52
Issue
4
Pages
943-946
Physical description
Dates
published
2005
received
2004-12-01
revised
2005-06-13
accepted
2005-06-30
(unknown)
2005-09-08
References
  • Berman DM, Wilkie TM, Gilman AG (1996) Cell 86: 445-452.
  • De Vries L, Mousli M, Wurmser A, Farquhar MG (1995) Proc Natl Acad Sci USA 92: 11916-11920.
  • Hollinger S, Hepler JR (2002) Pharmacol Rev 54: 527-559.
  • Jones PG, Macdonald SG, Cockett MI (2000) Expert Opin Ther Patents 9: 1-14.
  • Xin Li, Chaoneng Ji, Jiefeng Gu et al. (2005) Mol Biol Rep 32: 127-131.
  • Simon ML, Strathmann MP, Gautam N (1991) Science 252: 802-806.
  • Tesmer JJG, Berman DM, Gilman AG, Sprang SR (1997) Cell 89: 251-261.
  • Zheng B, De Vries L, Farquhar GM (1999) Trends Biochem Sci 24: 411-414.
  • Zhong H, Neubig RR (2001) J Pharmacol Exp Ther 297: 837-845.
Document Type
Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv52p943kz
Identifiers
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.