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2005 | 52 | 4 | 915-922
Article title

New spectrophotometric methods for the determination of nifedipine in pharmaceutical formulations

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EN
Abstracts
EN
Two simple, sensitive and economical spectrophotometric methods were developed for the determination of nifedipine in pharmaceutical formulations. Method A is based on the reaction of the nitro group of the drug with potassium hydroxide in dimethyl sulphoxide (DMSO) medium to form a coloured product, which absorbs maximally at 430 nm. Method B uses oxidation of the drug with ammonium molybdate and subsequently reduced molybdenum blue is measured at 830 nm. Beer's law is obeyed in the concentration range of 5.0-50.0 and 2.5-45.0 µg ml-1 with methods A and B, respectively. Both methods have been successfully applied for the assay of the drug in pharmaceutical formulations. No interference was observed from common pharmaceutical adjuvants. The reliability and the performance of the proposed methods are established by point and interval hypothesis tests and through recovery studies.
Publisher

Year
Volume
52
Issue
4
Pages
915-922
Physical description
Dates
published
2005
received
2005-03-22
revised
2005-10-06
accepted
2005-10-29
(unknown)
2005-11-07
Contributors
  • Department of Chemistry, Aligarh Muslim University, Aligarh, India
  • Department of Chemistry, Aligarh Muslim University, Aligarh, India
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv52p915kz
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