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2005 | 52 | 3 | 731-735

Article title

Retroviral targeting of proliferating endothelial cells

Content

Title variants

Languages of publication

EN

Abstracts

EN
Tumor growth requires the formation of new blood vessels by endothelial cells. Thus, surface molecules - such as angiogenin receptors - that are selectively expressed on growing endothelium represent an attractive target for directed delivery of compounds to tumor tissue. We attempted to obtain genetically engineered retroviral vectors targeted to the endothelium by inserting the human angiogenin sequence into Moloney murine leukemia virus envelope glycoprotein. Abundant expression of the chimeric protein could be verified. However, while being selective for proliferating human endothelial cells, the recombinant retroviral particles displayed low transduction efficiencies and thus have to be further improved.

Year

Volume

52

Issue

3

Pages

731-735

Physical description

Dates

published
2005
received
2005-03-15
revised
2005-08-02
accepted
2005-08-10

Contributors

  • Department of Surgery, Vienna General Hospital, Medical University of Vienna, Vienna, Austria
author
  • Department of Surgery, Vienna General Hospital, Medical University of Vienna, Vienna, Austria
  • Department of Surgery, Vienna General Hospital, Medical University of Vienna, Vienna, Austria
author
  • Department of Surgery, Vienna General Hospital, Medical University of Vienna, Vienna, Austria
  • Department of Surgery, Vienna General Hospital, Medical University of Vienna, Vienna, Austria

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.bwnjournal-article-abpv52i3p731kz
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