Retroviral targeting of proliferating endothelial cells

• Authors: Alexander Gornikiewicz , Anna Zommer , Raimund Jakesz , Michael Gnant , Christine Brostjan
• Languages of publication: EN

Abstracts

EN

Tumor growth requires the formation of new blood vessels by endothelial cells. Thus, surface molecules - such as angiogenin receptors - that are selectively expressed on growing endothelium represent an attractive target for directed delivery of compounds to tumor tissue. We attempted to obtain genetically engineered retroviral vectors targeted to the endothelium by inserting the human angiogenin sequence into Moloney murine leukemia virus envelope glycoprotein. Abundant expression of the chimeric protein could be verified. However, while being selective for proliferating human endothelial cells, the recombinant retroviral particles displayed low transduction efficiencies and thus have to be further improved.

Keywords

EN

targeting; endothelial cell; envelope glycoprotein; angiogenin; retrovirus

• Journal: Acta Biochimica Polonica
• Year: 2005
• Volume: 52
• Issue: 3
• Pages: 731-735

Dates

published

2005

received

2005-03-15

revised

2005-08-02

accepted

2005-08-10

Contributors

author

Alexander Gornikiewicz

• Department of Surgery, Vienna General Hospital, Medical University of Vienna, Vienna, Austria

author

Anna Zommer

• Department of Surgery, Vienna General Hospital, Medical University of Vienna, Vienna, Austria

author

Raimund Jakesz

• Department of Surgery, Vienna General Hospital, Medical University of Vienna, Vienna, Austria

author

Michael Gnant

• Department of Surgery, Vienna General Hospital, Medical University of Vienna, Vienna, Austria

author

Christine Brostjan

• Department of Surgery, Vienna General Hospital, Medical University of Vienna, Vienna, Austria

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