Molecular modelling of membrane activity of amphotericin B, a polyene macrolide antifungal antibiotic

• Authors: Maciej Baginski , Kamil Sternal , Jacek Czub , Edward Borowski
• Languages of publication: EN

Abstracts

EN

Amphotericin B (AmB) is a well known polyene macrolide antibiotic used to treat systemic fungal infections. Despite its toxicity AmB is still regarded as a life-saving drug. The lack of adequate knowledge of the AmB mechanism of action is a serious obstacle to efficient development of new less toxic derivatives. Complementary to various experimental approaches, computational chemistry methods were used to study AmB mechanism of action. A programme lasting for a decade, that was run by our group covered studies of: i) molecular properties of AmB and its membrane targets, ii) structure and properties of AmB membrane channels, and iii) interaction of AmB with the membrane.

Keywords

EN

antifungal agents; lipid membrane; cholesterol; amphotericin B; molecular modelling; ergosterol

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2005
• Volume: 52
• Issue: 3
• Pages: 655-658

Dates

published

2005

received

2005-03-15

revised

2005-06-06

accepted

2005-07-28

Contributors

author

Maciej Baginski

• Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, Gdańsk, Poland

author

Kamil Sternal

• Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, Gdańsk, Poland

author

Jacek Czub

• Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, Gdańsk, Poland

author

Edward Borowski

• Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdańsk University of Technology, Gdańsk, Poland

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