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2005 | 52 | 3 | 655-658
Article title

Molecular modelling of membrane activity of amphotericin B, a polyene macrolide antifungal antibiotic

Content
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EN
Abstracts
EN
Amphotericin B (AmB) is a well known polyene macrolide antibiotic used to treat systemic fungal infections. Despite its toxicity AmB is still regarded as a life-saving drug. The lack of adequate knowledge of the AmB mechanism of action is a serious obstacle to efficient development of new less toxic derivatives. Complementary to various experimental approaches, computational chemistry methods were used to study AmB mechanism of action. A programme lasting for a decade, that was run by our group covered studies of: i) molecular properties of AmB and its membrane targets, ii) structure and properties of AmB membrane channels, and iii) interaction of AmB with the membrane.
Year
Volume
52
Issue
3
Pages
655-658
Physical description
Dates
published
2005
received
2005-03-15
revised
2005-06-06
accepted
2005-07-28
References
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Document Type
Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv52i3p655kz
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