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2005 | 52 | 2 | 557-560
Article title

Fibronectin fragments in human seminal plasma.

Content
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Languages of publication
EN
Abstracts
EN
The study has revealed the presence of fibronectin (FN) fragments and a lack of intact FN in 72 seminal plasma samples. The FN fragmentation was examined by immunoblotting with a monoclonal antibody specific to the central cellular FN domain and was confirmed with a monoclonal antibody directed to the C-terminal domain of FN. Nine FN fragments between 60 and 200 kDa and five fragments of 60-150 kDa were identified in seminal plasma samples of normozoospermic and of terato-, oligoterato-, and oligoasthenoterato-spermic groups, respectively. The relative amounts of the 60, 90 and 100 kDa FN fragments were 2-3 times higher in seminal plasmas with abnormal semen characteristics than in the normozoospermic group. The results suggest that seminal plasma FN fragments may contribute to fertilization and the analysis of FN fragmentation may have a diagnostic value in andrological investigations.
Publisher

Year
Volume
52
Issue
2
Pages
557-560
Physical description
Dates
published
2005
received
2004-05-13
revised
2004-11-22
accepted
2004-12-10
(unknown)
2005-05-15
Contributors
  • Department of Chemistry and Immunochemistry, Medical University, Wrocław, Poland
  • Department of Chemistry and Immunochemistry, Medical University, Wrocław, Poland
  • Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv52i2p557kz
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