Pre-eclampsia-associated alterations in Wharton's jelly proteoglycans.

• Authors: Tomasz Gogiel , Zofia Galewska , Stefan Jaworski
• Languages of publication: EN

Abstracts

EN

Proteoglycans of Wharton's jelly contain mainly chondroitin/dermatan sulphate chains. The predominant proteoglycan is decorin (core proteins of 45 and 47 kDa), although the core proteins of biglycan (45 kDa), versican (260 kDa) and of other proteoglycans (90, 110, 220 kDa) were also detected (Gogiel et al., 2003). The aim of the present study was to compare the proteoglycan composition of Wharton's jelly of newborns delivered by healthy mothers and those with pre-eclampsia. Proteoglycans from pre-eclamptic Wharton's jelly had a higher sulphated glycosaminoglycan/protein ratio than those of normal tissue. Pre-eclampsia is associated with a lower level of all proteoglycan core proteins, especially those of higher molecular mass (such as versican), although the same set of core proteins were found in normal and pre-eclamptic Wharton's jelly. The alterations in the proteoglycan composition of Wharton's jelly may affect the mechanical properties of the umbilical cord and, in the case of pre-eclampsia, disturb foetal blood circulation.

Keywords

EN

umbilical cord; proteoglycans; Wharton's jelly; glycosaminoglycans; pre-eclampsia

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2005
• Volume: 52
• Issue: 2
• Pages: 501-507

Dates

published

2005

received

2004-06-23

revised

2004-12-15

accepted

2005-01-01

(unknown)

2005-05-15

Contributors

author

Tomasz Gogiel

• Department of Medical Biochemistry, Medical Academy of Białystok, Białystok, Poland

author

Zofia Galewska

• Department of Medical Biochemistry, Medical Academy of Białystok, Białystok, Poland

author

Stefan Jaworski

• Department of Gynaecology, Medical Academy of Białystok, Białystok, Poland

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