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2005 | 52 | 2 | 353-358
Article title

Stem cell biology - a never ending quest for understanding.

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EN
Abstracts
EN
Stem cells (SC) research is an important part of biotechnology that could lead to the development of new therapeutic strategies. A lot of effort has been put to understand biology of the stem cells and to find genes and subsequently proteins that are responsible for their proliferation, self-renewal and differentiation. Different cytokines and growth factors has been used to expand stem cells, but no combination of these factors was identified that could effectively expand the most primitive stem cells. Recently, however, genes and receptors responsible for SC proliferation and differentiation have been described. Ligands for these receptors or these genes themselves are being already used for ex vivo expansion of stem cells and the first data are very promising. New markers, such as CXCR4 and CD133, have been discovered and shown to be present on surface of hematopoietic stem cells. The same markers were recently also found to be expressed on neuronal-, hepatic- or skeletal muscle-stem cells. By employing these markers several laboratories are trying to isolate stem cells for potential clinical use. New characteristics of stem cells such as transdifferentiation and cell fusion have been described. Our team has identified a population of tissue committed stem cells (TCSC). These cells are present in a bone marrow and in other tissues and they can differentiate into several cell types including cardiac, neural and liver cells.
Keywords
EN
Publisher

Year
Volume
52
Issue
2
Pages
353-358
Physical description
Dates
published
2005
received
2005-04-25
revised
2005-05-31
accepted
2005-06-08
(unknown)
2005-06-25
Contributors
author
  • Department of Transplantation, Jagiellonian University Medical College, Cracow, Poland
  • Stem Cells Biology Program, James Graham Brawn Cancer Center, University of Louisville, Louisville, KY, USA
  • Department of Transplantation, Jagiellonian University Medical College, Cracow, Poland
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv52i2p353kz
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