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2005 | 52 | 2 | 321-328
Article title

Prospects for p53-based cancer therapy.

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Abstracts
EN
The p53 tumor suppressor plays the role of a cellular hub which gathers stress signals such as damage to DNA or hypoxia and translates them into a complex response. p53 exerts its action mainly as a potent transcription factor. The two major outcomes of p53 activity are highlighted: cell cycle arrest and apoptosis. During malignant transformation p53 or p53-pathway related molecules are disabled extremely often. Mutations in p53 gene are present in every second human tumor. A mutant form of p53 may not only negate the wild type p53 function but may play additional role in tumor progression. Therefore p53 represents a relatively unique and specific target for anticancer drug design. Current approaches include several different molecules able to restore p53 wild-type conformation and activity. Such small molecule drugs hold great promise in treating human tumors with dysfunction of p53 pathway in the near future.
Year
Volume
52
Issue
2
Pages
321-328
Physical description
Dates
published
2005
received
2005-04-05
revised
2005-06-13
accepted
2005-06-16
(unknown)
2005-06-25
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Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv52i2p321kz
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