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2005 | 52 | 2 | 311-319
Article title

Inhibition and regression of atherosclerotic lesions.

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EN
Abstracts
EN
Atherosclerosis, once believed to be a result of a slow, irreversible process resulting from lipid accumulation in arterial walls, is now recognized as a dynamic process with reversibility. Liver-directed gene therapy for dyslipidemia aims to treat patients who are not responsive to currently available primary and secondary prevention. Moreover, gene therapy strategies have also proved valuable in studying the dynamics of atherosclerotic lesion formation, progression, and remodeling in experimental animals. Recent results on the long-term effect of gene therapy suggest that hepatic expression of therapeutic genes suppresses inflammation and has profound effects on the nature of the atherogenic process.
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Year
Volume
52
Issue
2
Pages
311-319
Physical description
Dates
published
2005
received
2005-04-05
revised
2005-04-15
accepted
2005-05-31
(unknown)
2005-06-03
Contributors
author
  • Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, USA
author
  • Department of Medicine, Baylor College of Medicine, Houston, USA
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Publication order reference
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YADDA identifier
bwmeta1.element.bwnjournal-article-abpv52i2p311kz
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