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2004 | 51 | 4 | 1067-1073
Article title

Monocytes in children with leukemias and lymphomas - down-regulation of HLA and costimulatory molecules.

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EN
Abstracts
EN
The aim of the study was to evaluate the function of monocytes in children with leukemias and lymphomas based on the expression of critical costimulatory, activatory and adhesion molecules (CD80, CD86, HLA-DR and CD54 = ICAM-1), estimated with tricolor flow cytometry. In comparison to the control group we found a lower percentage of monocytes with costimulatory molecules (CD80 before and CD86 after lipopolysaccharide stimulation) at the time of diagnosis and of monocytes with HLA-DR molecules after remission induction. We also noted a lower percentage of monocytes with HLA-DR expression in the group with severe or therapy resistant infections. The results of our investigation suggest some defect in costimulation and antigen presentation in lymphoproliferative diseases in children.
Keywords
Publisher

Year
Volume
51
Issue
4
Pages
1067-1073
Physical description
Dates
published
2004
received
2004-06-16
accepted
2004-10-18
revised
2004-10-22
Contributors
  • Department of Pediatric Oncology, Medical University of Białystok, Białystok, Poland
  • Department of Flow Cytometry, Children's University Hospital, Białystok, Poland
  • Department of Pediatric Oncology, Medical University of Białystok, Białystok, Poland
  • Department of Pediatric Oncology, Medical University of Białystok, Białystok, Poland
  • Department of Pediatrics, Hematology and Oncology, Medical University of Warsaw, Warsaw, Poland
  • Department of Pediatric Hematology and Oncology, Medical University of Lublin, Lublin, Poland
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv51i4p1067kz
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