Monocytes in children with leukemias and lymphomas - down-regulation of HLA and costimulatory molecules.

• Authors: Włodzimierz Łuczyński , Anna Stasiak-Barmuta , Maryna Krawczuk-Rybak , Marcin Szymański , Iwona Malinowska , Małgorzata Mitura-Lesiuk
• Languages of publication: EN

Abstracts

EN

The aim of the study was to evaluate the function of monocytes in children with leukemias and lymphomas based on the expression of critical costimulatory, activatory and adhesion molecules (CD80, CD86, HLA-DR and CD54 = ICAM-1), estimated with tricolor flow cytometry. In comparison to the control group we found a lower percentage of monocytes with costimulatory molecules (CD80 before and CD86 after lipopolysaccharide stimulation) at the time of diagnosis and of monocytes with HLA-DR molecules after remission induction. We also noted a lower percentage of monocytes with HLA-DR expression in the group with severe or therapy resistant infections. The results of our investigation suggest some defect in costimulation and antigen presentation in lymphoproliferative diseases in children.

Keywords

EN

infection; lymphoma; costimulation; leukemia; monocytes

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2004
• Volume: 51
• Issue: 4
• Pages: 1067-1073

Dates

published

2004

received

2004-06-16

accepted

2004-10-18

revised

2004-10-22

Contributors

author

Włodzimierz Łuczyński

• Department of Pediatric Oncology, Medical University of Białystok, Białystok, Poland

author

Anna Stasiak-Barmuta

• Department of Flow Cytometry, Children's University Hospital, Białystok, Poland

author

Maryna Krawczuk-Rybak

• Department of Pediatric Oncology, Medical University of Białystok, Białystok, Poland

author

Marcin Szymański

• Department of Pediatric Oncology, Medical University of Białystok, Białystok, Poland

author

Iwona Malinowska

• Department of Pediatrics, Hematology and Oncology, Medical University of Warsaw, Warsaw, Poland

author

Małgorzata Mitura-Lesiuk

• Department of Pediatric Hematology and Oncology, Medical University of Lublin, Lublin, Poland

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