Preferences help
enabled [disable] Abstract
Number of results
2004 | 51 | 4 | 1067-1073
Article title

Monocytes in children with leukemias and lymphomas - down-regulation of HLA and costimulatory molecules.

Title variants
Languages of publication
The aim of the study was to evaluate the function of monocytes in children with leukemias and lymphomas based on the expression of critical costimulatory, activatory and adhesion molecules (CD80, CD86, HLA-DR and CD54 = ICAM-1), estimated with tricolor flow cytometry. In comparison to the control group we found a lower percentage of monocytes with costimulatory molecules (CD80 before and CD86 after lipopolysaccharide stimulation) at the time of diagnosis and of monocytes with HLA-DR molecules after remission induction. We also noted a lower percentage of monocytes with HLA-DR expression in the group with severe or therapy resistant infections. The results of our investigation suggest some defect in costimulation and antigen presentation in lymphoproliferative diseases in children.
Physical description
  • Department of Pediatric Oncology, Medical University of Białystok, Białystok, Poland
  • Department of Flow Cytometry, Children's University Hospital, Białystok, Poland
  • Department of Pediatric Oncology, Medical University of Białystok, Białystok, Poland
  • Department of Pediatric Oncology, Medical University of Białystok, Białystok, Poland
  • Department of Pediatrics, Hematology and Oncology, Medical University of Warsaw, Warsaw, Poland
  • Department of Pediatric Hematology and Oncology, Medical University of Lublin, Lublin, Poland
  • Abendroth A, Slobedman B, Lee E, Mellins E, Wallace M, Arvin A. (2000) J Virol.; 74: 1900-7.
  • Amaraa R, Mareckova H, Urbanek P, Fucikova T. (2002) Immunol Lett.; 83: 209-14.
  • Ampel NM, Christian L. (2000) Med Mycol.; 38: 127-32.
  • Balbo P, Silvestri M, Rossi GA, Crimi E, Burastero SE. (2001) Clin Exp Allergy.; 31: 625-36.
  • Berthier-Vergnes O, Gaucherand M, Peguet-Navarro J, Plouet J, Pageaux JF, Schmitt D, Staquet MJ. (2001) Br J Cancer.; 85: 1944-51.
  • Brown RD, Pope B, Murray A, Esdale W, Sze DM, Gibson J, Ho PJ, Hart D, Joshua D. (2001) Blood.; 98: 2992-8.
  • Carrillo EH, Gordon L, Goode E, Davis E, Polk HC. (2001) J Trauma.; 50: 810-6
  • Contreras JAV. (1999) Clin Chem Lab Med.; 37: 607-22.
  • Docke W-D, Randow F, Syrbe U, Krausch D, Asadullah K, Reinke P, Volk H-D, Kox W. (1997) Nat Med.; 3: 678-81.
  • Hoflich C, Docke WD, Meisel C, Volk HD. (2002) Clin Appl Immunol Rev.; 2: 337-44.
  • Loercher AE, Nash MA, Kavanagh JJ, Platsoucas CD, Freedman RS. (1999) J Immunol.; 163: 6251-60.
  • Melichar B, Nash MA, Lenzi R, Platsoucas CD, Freedman RS. (2000) Clin Exp Immunol.; 119: 19-27.
  • Michałkiewicz J, Stachowski J, Barth C, Patzer J, Dzierżanowska D, Madalinski K. (1999) Immunol Lett.; 69: 359-66.
  • Orsini E, Guardini A, Chiaretti S, Mauro FR, Foa R. (2003) Cancer Res.; 63: 4497-506.
  • Papadopoulos NG, Stanciu LA, Papi A, Holgate ST, Johnston SL. (2002) Clin Exp Allergy.; 32: 537-42.
  • Paquette RL, Hsu N, Said J, Mohammed M, Rao NP, Shih G, Schiller G, Sawyers C, Glaspy JA. (2002) Leukemia.; 16: 1484-9.
  • Ratta M, Fagnoni F, Curti A, Vescovini R, Sansoni P, Oliviero B, Fogli M, Ferri E. (2002) Blood.; 100: 230-7.
  • Rezvany MR, Jeddi-Tehrani M, Biberfeld P, Soderlund J, Mellstedt H, Osterborg A, Rabbani H. (2001) Br J Haematol.; 115: 263-71.
  • Savary CA, Grazziutti ML, Melichar B, Przepiorka D, Freedman RS, Cowart RE, Cohen DM, Anaisse EJ, Woodside DG, McIntyre BW, Pireson DL, Pellis NR, Rex JH. (1998) Cancer Immunol Immunother.; 45: 234-40.
  • Taylor JV, Gordon LE, Polk HC. (2000) Clin Exp Immunol.; 122: 308.
  • Ugurel S, Uhlig D, Pfohler C, Tilgen W, Schadendorf D, Reinhold U. (2004) Cancer Immunol Immunother.; 53: 551-9.
  • Wang C, Al-Omar HM, Radvanyi L, Banerjee A, Bouman D, Squire J, Messner HA. (1999) Exp Hematol.; 27: 1176-84.
  • Wang SZ, Hallsworth PG, Dowling KD, Alpers JH, Bowden JJ, Forsyth KD. (2000) Eur Respir J.; 15: 358-66.
Document Type
Publication order reference
YADDA identifier
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.