Activity of lysosomal exoglycosidases in submandibular glands of rats intoxicated by cadmium at doses related to human chronic environmental and occupational exposures.

• Authors: Anna Zalewska , Małgorzata M Brzó ska , Justyna Marciniak , Katarzyna Karaszewska , Krzysztof Zwierz , Janina Moniuszko-Jakoniuk
• Languages of publication: EN

Abstracts

EN

Work in cadmium (Cd) smelter and smoking cigarettes damages teeth and oral mucosa which are protected by tissue and salivary glycoconjugates: glycoproteins, glycolipids, and proteoglycans. We worked out a rat model imitating human "environmental" and "occupational" exposure to cadmium using 5 mg Cd and 50 mg Cd/l in drinking water, respectively. In submandibulary glands of exposed to Cd rats, we found the time and dose dependent accumulation of Cd and simultanous decrease in activity of β-N-acetylhexosaminidase (HEX). In homogenates of submandibulary glands of control rats, β-N-acetylhexosaminidase showed the highest activity. The activities of α;-mannosidase and β-galactosidase were very low. None of these exoglycosidases were inhibited by Cd even at 44 mM concentration.

Keywords

EN

exoglycosidases; β-galactosidase; α-mannosidase; cadmium; salivary glands of rats; β-N-acetylhexosaminidase

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2004
• Volume: 51
• Issue: 3
• Pages: 831-837

Dates

published

2004

received

2003-03-06

revised

2004-01-12

accepted

2004-02-25

Contributors

author

Anna Zalewska

• Department of Pharmaceutical Biochemistry, Medical University of Bialystok, Białystok, Poland

author

Małgorzata M Brzó ska

• Department of Toxicology, Medical University of Bialystok, Białystok, Poland

author

Justyna Marciniak

• Department of Pharmaceutical Biochemistry, Medical University of Bialystok, Białystok, Poland

author

Katarzyna Karaszewska

• Department of Pharmaceutical Biochemistry, Medical University of Bialystok, Białystok, Poland

author

Krzysztof Zwierz

• Department of Pharmaceutical Biochemistry, Medical University of Bialystok, Białystok, Poland

author

Janina Moniuszko-Jakoniuk

• Department of Toxicology, Medical University of Bialystok, Białystok, Poland

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