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2004 | 51 | 3 | 831-837
Article title

Activity of lysosomal exoglycosidases in submandibular glands of rats intoxicated by cadmium at doses related to human chronic environmental and occupational exposures.

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Work in cadmium (Cd) smelter and smoking cigarettes damages teeth and oral mucosa which are protected by tissue and salivary glycoconjugates: glycoproteins, glycolipids, and proteoglycans. We worked out a rat model imitating human "environmental" and "occupational" exposure to cadmium using 5 mg Cd and 50 mg Cd/l in drinking water, respectively. In submandibulary glands of exposed to Cd rats, we found the time and dose dependent accumulation of Cd and simultanous decrease in activity of β-N-acetylhexosaminidase (HEX). In homogenates of submandibulary glands of control rats, β-N-acetylhexosaminidase showed the highest activity. The activities of α;-mannosidase and β-galactosidase were very low. None of these exoglycosidases were inhibited by Cd even at 44 mM concentration.
Physical description
  • Department of Pharmaceutical Biochemistry, Medical University of Bialystok, Białystok, Poland
  • Department of Toxicology, Medical University of Bialystok, Białystok, Poland
  • Department of Pharmaceutical Biochemistry, Medical University of Bialystok, Białystok, Poland
  • Department of Pharmaceutical Biochemistry, Medical University of Bialystok, Białystok, Poland
  • Department of Pharmaceutical Biochemistry, Medical University of Bialystok, Białystok, Poland
  • Department of Toxicology, Medical University of Bialystok, Białystok, Poland
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