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2004 | 51 | 3 | 815-824
Article title

Plasma levels of total, free and protein bound thiols as well as sulfane sulfur in different age groups of rats

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EN
Abstracts
EN
The redox status of plasma thiols can be a diagnostic indicator of different pathological states. The aim of this study was to identify the age dependent changes in the plasma levels of total, free and protein bound glutathione, cysteine and homocysteine. The determination was conducted in plasma of three groups of rats: 1) young (3-month-old), 2) middle aged (19-month-old), and 3) old (31-month-old). Total levels of glutathione, cysteine and homocysteine and their respective free and protein-bound fractions decreased with age. The only exception was a rise in free homocysteine concentration in the middle group, which indicates a different pattern of transformations of this thiol in plasma. The drop in the level of protein-bound thiols suggests that the antioxidant capacity of plasma diminishes with age, which, consequently, leads to impaired protection of -SH groups through irreversible oxidation. The plasma sulfane sulfur level also declines with age, which means that aging is accompanied by inhibition of anaerobic sulfur metabolism.
Keywords
Publisher

Year
Volume
51
Issue
3
Pages
815-824
Physical description
Dates
published
2004
received
2003-11-19
revised
2004-04-01
accepted
2004-05-17
Contributors
  • Institute of Medical Biochemistry, Collegium Medicum, Jagiellonian University, Kraków, Poland
  • Department of Environmental Chemistry, University of Łódź, Łódź, Poland
  • Department of Neuropsychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland
author
  • Department of Environmental Chemistry, University of Łódź, Łódź, Poland
author
  • Institute of Medical Biochemistry, Collegium Medicum, Jagiellonian University; Kraków, Kraków, Poland
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Document Type
Publication order reference
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YADDA identifier
bwmeta1.element.bwnjournal-article-abpv51i3p815kz
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