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2004 | 51 | 2 | 481-492
Article title

Slowing down aging from within: mechanistic aspects of anti-aging hormetic effects of mild heat stress on human cells.

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EN
Abstracts
EN
Since aging is primarily the result of a failure of maintenance and repair mechanisms, various approaches are being developed in order to stimulate these pathways and modulate the process of aging. One such approach, termed hormesis, involves challenging cells and organisms by mild stress that often results in anti-aging and life prolonging effects. In a series of experimental studies, we have reported that repeated mild heat stress (RMHS) has anti-aging hormetic effects on growth and various cellular and biochemical characteristics of human skin fibroblasts undergoing aging in vitro. These beneficial effects of repeated challenge include the maintenance of stress protein profile, reduction in the accumulation of oxidatively and glycoxidatively damaged proteins, stimulation of the proteasomal activities for the degradation of abnormal proteins, improved cellular resistance to other stresses, and enhanced levels of cellular antioxidant ability. In order to elucidate the molecular mechanisms of hormetic effects of RMHS, we are now undertaking studies on signal transduction pathways, energy production and utilisation kinetics, and the proteomic analysis of patterns of proteins synthesised and their posttranslational modifications in various types of human cells undergoing cellular aging in vitro. Human applications of hormesis include early intervention and modulation of the aging process to prevent or delay the onset of age-related conditions, such as sarcopenia, Alzheimer's disease, Parkinson's disease, cataracts and osteoporosis.
Year
Volume
51
Issue
2
Pages
481-492
Physical description
Dates
published
2004
received
2004-04-05
accepted
2004-04-14
References
  • Adler V, Dolan LR, Kim JE, Pincus M, Barrett JC, Ronai Z. (1996) Changes in jun N-terminal kinase activation by stress during aging of cultured normal human fibroblasts. Mol Carcinog.; 17: 8-12.
  • Anson RM, Guo Z, de Cabo R, Lyun T, Rios M, Hagepanos A, Ingram DK, Lane MA, Mattson MP. (2003) Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie restriction. Proc Natl Acad Sci USA.; 100: 6216-20.
  • Beedholm R, Clark BFC, Rattan SIS. (2004) Mild heat stress stimulates proteasome and its 11S activator in human fibroblasts undergoing aging in vitro. Cell Stress Chaperones.; 9: 49-57.
  • Boraldi F, Bini L, Liberatori S, Armini A, Pallini V, Tiozzo R, Pasquali-Ronchetti I, Quaglino D. (2003) Proteome analysis of dermal fibroblasts cultured in vitro from human healthy subjects of different ages. Proteomics.; 3: 917-29.
  • Brégégére F, Sooka Y, Bismuth J, Friguet B, Milner Y. (2003) Cellular senescence in human keratinocytes: unchanged proteolytic capacity and increased protein load. Exp Gerontol.; 38: 619-29.
  • Buchner J. (1999) Hsp90 & Co. - a holding for folding. Trends Biochem Sci.; 24: 136-41.
  • Bulteau AL, Petropoulos I, Friguet B. (2000) Age-related alterations of proteasome structure and function in aging epidermis. Exp Gerontol.; 35: 767-77.
  • Calabrese EJ, Baldwin LA. (2000a) The effects of gamma rays on longevity. Biogerontology.; 1: 309-19.
  • Calabrese EJ, Baldwin LA. (2000b) Tales of two similar hypotheses: the rise and fall of chemical and radiation hormesis. Hum Exp Toxicol.; 19: 85-97.
  • Carnes BA, Olshansky SJ, Grahn D. (2003) Biological evidence for limits to the duration of life. Biogerontology.; 4: 31-45.
  • Carrard G, Bulteau AL, Petropoulos I, Friguet B. (2002) Impairment of proteasome structure and function in aging. Int J Biochem Cell Biol.; 34: 1461-74.
  • Carrard G, Dieu M, Raes M, Toussaint O, Friguet B. (2003) Impact of ageing on proteasome structure and function in human lymphocytes. Int J Biochem Cell Biol.; 35: 728-39.
  • Chondrogianni N, Stratford FLL, Trougakos IP, Friguet B, Rivett AJ, Gonos ES. (2003) Central role of the proteasome in senescence and survival of human fibroblasts. J Biol Chem.; 278: 28026-37.
  • Conconi M, Friguet B. (1997) Proteasome inactivation upon aging and on oxidation-effect of HSP90. Mol Biol Rep.; 24: 45-50.
  • Cuervo AM, Dice JF. (2000a) Age-related decline in chaperone-mediated autophagy. J Biol Chem.; 275: 31505-13.
  • Cuervo AM, Dice JF. (2000b) When lysosomes get old. Exp Gerontol.; 35: 119-31.
  • Cypser JR, Johnson TE. (2003) Hormesis in Caenorhabditis elagans dauer-defective mutants. Biogerontology.; 4: 203-14.
  • Dorion S, Landry J. (2002) Activation of the mitogen-activated protein kinase pathways by heat shock. Cell Stress Chaperones.; 7: 200-6.
  • Dröge W. (2004) Autophagy and aging - importance of amino acid levels. Mech Ageing Dev.; 125: 161-8.
  • Dukan S, Farewell A, Ballesteros M, Taddei F, Rodman M, Nystrom T. (2000) Protein oxidation in response to increased transcriptional or translational errors. Proc Natl Acad Sci USA.; 97: 5746-9.
  • Fonager J, Beedholm R, Clark BFC, Rattan SIS. (2002) Mild stress-induced stimulation of heat shock protein synthesis and improved functional ability of human fibroblasts undergoing aging in vitro. Exp Gerontol.; 37: 1223-38.
  • Grune T. (2000) Oxidative stress, aging and the proteasomal system. Biogerontology.; 1: 31-40.
  • Hallén A. (2002) Accumulation of insoluble protein and aging. Biogerontology.; 3: 307-15.
  • Harris N, MacLean M, Hatzianthis K, Panaretou B, Piper PW. (2001) Increasing Saccharomyces cerevisiae stress resistance, through the overactivation of the heat shock response resulting from defects in the Hsp90 chaperone, does not extend replicative life span but can be associated with slower chronological ageing of nondividing cells. Mol Genet Genomics.; 265: 258-63.
  • Hercus MJ, Loeschcke V, Rattan SIS. (2003) Lifespan extension of Drosophila melanogaster through hormesis by repeated mild heat stress. Biogerontology.; 4: 149-56.
  • Holliday R. (1995) Understanding Ageing. Cambridge, University Press, Cambridge.
  • Kiang JG, Tsokos GC. (1998) Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology. Pharmacol Ther.; 80: 183-201.
  • Kiang JG, McClain DE. (2003) Heat stress. In: Combat Medicine: Basic and Clinical Research in Military, Trauma, and Emergency Medicine; Tsokos GC, Atkins JL. eds, pp 83-101. Humana Press. New Jersey.
  • King V, Tower J. (1999) Aging-specific expression of Drosophila hsp22. Dev Biol.; 207: 107-18.
  • Le Bourg E, Minois N, Bullens P, Baret P. (2000) A mild stress due to hypergravity exposure at young age increases longevity in Drosophila melanogaster males. Biogerontology.; 1: 145-55.
  • Lee CK, Klopp RG, Weindruch R, Prolla TA. (1999) Gene expression profile of aging and its retardation by caloric restriction. Science.; 285: 1390-3.
  • Lin RZ, Hu ZW, Chin JH, Hoffman BB. (1997) Heat shock activates c-Src tyrosine kinase and phosphatidylinositol 3-kinase in NIH3T3 fibroblasts. J Biol Chem.; 272: 31196-202.
  • Lorenzini A, Tresini M, Mawal-Dewan M, Frisoni L, Zhang H, Allen RG, Sell C, Cristofalo VJ. (2002) Role of the Raf/MEK/ERK and the PI3K/Akt(PKB) pathways in fibroblast senescence. Exp Gerontol.; 37: 1149-56.
  • Maiello M, Boeri D, Sampietro L, Pronzato MA, Odetti P, Marinari UM. (1997) Basal synthesis of heat shock protein 70 increases with age in rat kidneys. Gerontology.; 44: 15-20.
  • Masoro EJ. (2000) Caloric restriction and aging: an update. Exp Gerontol.; 35: 299-305.
  • Meriin AB, Yaglom JA, Gabai VL, Zon L, Ganiatsas S, Mosser DD, Sherman MY. (1999) Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72. Mol Cell Biol.; 19: 2547-55.
  • Minois N. (2000) Longevity and aging: beneficial effects of exposure to mild stress. Biogerontology.; 1: 15-29.
  • Park J, Liu YC. (2001) JNK phosphorylates the HSF1 transcriptional activation domain: role of JNK in the regulation of the heat shock response. J Cell Biochem.; 82: 326-38.
  • Préville X, Salvemini F, Giraud S, Chafour S, Paul C, Stepien G, Ursini MV, Arrigo AP. (1999) Mammalian small stress proteins protect against oxidative stress through their ability to increase glucose-6-phosphate dehydrogenase activity and by maintaining optimal cellular detoxifying machinery. Exp Cell Res.; 247: 61-78.
  • Raji NS, Surekha A, Subba Rao K. (1998) Improved DNA-repair parameters in PHA-stimulated peripheral blood lymphocytes of human subjects with low body mass index. Mech Ageing Dev.; 104: 133-48.
  • Rattan SIS. (1995) Gerontogenes: real or virtual? FASEB J.; 9: 284-6.
  • Rattan SIS. (1998) Repeated mild heat shock delays ageing in cultured human skin fibroblasts. Biochem Mol Biol Int.; 45: 753-9.
  • Rattan SIS. (2000a) Ageing, gerontogenes, and hormesis. Indian J Exp Biol.; 38: 1-5.
  • Rattan SIS. (2000b) Biogerontology: the next step. Ann NY Acad Sci.; 908: 282-90.
  • Rattan SIS. (2001) Applying hormesis in aging research and therapy. Hum Exp Toxicol.; 20: 281-5.
  • Rattan SIS. (2004) Aging, anti-aging, and hormesis. Mech Ageing Dev.; 125: 285-9.
  • Rutherford SL, Lindquist S. (1998) Hsp90 as a capacitor for morphological evolution. Nature.; 396: 336-42.
  • Shringaarpure R, Davies KJA. (2002) Protein turnover by the proteasome in aging and disease. Free Radic Biol Med.; 32: 1084-9.
  • Söti C, Csermely P. (2000) Molecular chaperones and the aging process. Biogerontology.; 1: 225-33.
  • Söti C, Sreedhar AS, Csermely P. (2003) Apoptosis, necrosis and cellular senescence: chaperone occupancy as a potential switch. Aging Cell.; 2: 39-45.
  • Suh Y. (2002) Cell signaling in aging and apoptosis. Mech Ageing Dev.; 123: 881-90.
  • Terman A, Brunk UT. (1998) Ceroid/lipofuscin formation in cultured human fibroblasts: the role of oxidative stress and proteolysis. Mech Ageing Dev.; 104: 277-91.
  • Terman A, Abrahamsson N, Brunk UT. (1999) Ceroid/lipofuscin-loaded human fibroblasts show increased susceptibility to oxidative stress. Exp Gerontol.; 34: 755-70.
  • Verbeke P, Clark BFC, Rattan SIS. (2000) Modulating cellular aging in vitro: hormetic effects of repeated mild heat stress on protein oxidation and glycation. Exp Gerontol.; 35: 787-94.
  • Verbeke P, Clark BFC, Rattan SIS. (2001a) Reduced levels of oxidized and glycoxidized proteins in human fibroblasts exposed to repeated mild heat shock during serial passaging in vitro. Free Radic Biol Med.; 31: 1593-602.
  • Verbeke P, Fonager J, Clark BFC, Rattan SIS. (2001b) Heat shock response and ageing: mechanisms and applications. Cell Biol Int.; 25: 845-57.
  • Verbeke P, Deries M, Clark BFC, Rattan SIS. (2002) Hormetic action of mild heat stress decreases the inducibility of protein oxidation and glycoxidation in human fibroblasts. Biogerontology.; 3: 117-21.
  • Volloch V, Mosser DD, Massie B, Sherman MY. (1998) Reduced thermotolerance in aged cells results from loss of an hsp72-mediated control of JNK signaling pathway. Cell Stress Chaperones.; 3: 265-71.
  • Wagner BJ, Margolis JW. (1995) Age-dependent association of isolated bovine lens multicatalytic proteinase complex (proteasome) with heat shock protein 90, and endogeneous inhibitor. Arch Biochem Biophys.; 323: 455-62.
  • Wang MC, Bohmann D, Jasper H. (2003) JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila. Dev Cell.; 5: 811-6.
  • Widmann C, Gibson S, Jarpe MB, Johnson GL. (1999) Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev.; 79: 143-80.
Document Type
Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv51i2p481kz
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