New analogue of cyclolinopeptide B modified by amphiphilic residue of α-hydroxymethylmethionine.

• Authors: Renata Witkowska , Anna Donigiewicz , Michał Zimecki , Janusz Zabrocki
• Languages of publication: EN

Abstracts

EN

In order to evaluate the role and influence of the methionine residue on the biological activity of cyclolinopeptide B, an analogue with methionine residue in position 7 replaced by the amphiphilic (S)-a-hydroxymethylmethionine residue was synthesized. This peptide exhibits high immunosuppressive activity in the cellular, and to a lesser degree in the humoral immune response, comparable to that of CsA. In addition, the peptide was devoid of toxicity, even at high doses.

Keywords

EN

α-hydroksymethylmethionine; analogue of cyclolinopeptide B; α-hydroksymethylamino acids

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2004
• Volume: 51
• Issue: 1
• Pages: 67-72

Dates

published

2004

received

2003-10-31

revised

2004-01-27

accepted

2004-02-08

Contributors

author

Renata Witkowska

• Institute of Organic Chemistry, Technical University of Łódź, Łódź, Poland

author

Anna Donigiewicz

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland

author

Michał Zimecki

• Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland

author

Janusz Zabrocki

• Institute of Organic Chemistry, Technical University of Łódź, Łódź, Poland

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