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2004 | 51 | 1 | 67-72
Article title

New analogue of cyclolinopeptide B modified by amphiphilic residue of α-hydroxymethylmethionine.

Content
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Languages of publication
EN
Abstracts
EN
In order to evaluate the role and influence of the methionine residue on the biological activity of cyclolinopeptide B, an analogue with methionine residue in position 7 replaced by the amphiphilic (S)-a-hydroxymethylmethionine residue was synthesized. This peptide exhibits high immunosuppressive activity in the cellular, and to a lesser degree in the humoral immune response, comparable to that of CsA. In addition, the peptide was devoid of toxicity, even at high doses.
Publisher

Year
Volume
51
Issue
1
Pages
67-72
Physical description
Dates
published
2004
received
2003-10-31
revised
2004-01-27
accepted
2004-02-08
Contributors
  • Institute of Organic Chemistry, Technical University of Łódź, Łódź, Poland
  • Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
  • Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
  • Institute of Organic Chemistry, Technical University of Łódź, Łódź, Poland
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv51i1p67kz
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