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2004 | 51 | 1 | 67-72
Article title

New analogue of cyclolinopeptide B modified by amphiphilic residue of α-hydroxymethylmethionine.

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In order to evaluate the role and influence of the methionine residue on the biological activity of cyclolinopeptide B, an analogue with methionine residue in position 7 replaced by the amphiphilic (S)-a-hydroxymethylmethionine residue was synthesized. This peptide exhibits high immunosuppressive activity in the cellular, and to a lesser degree in the humoral immune response, comparable to that of CsA. In addition, the peptide was devoid of toxicity, even at high doses.
Physical description
  • Institute of Organic Chemistry, Technical University of Łódź, Łódź, Poland
  • Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
  • Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
  • Institute of Organic Chemistry, Technical University of Łódź, Łódź, Poland
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