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2004 | 51 | 1 | 57-66
Article title

On the peptide-antipeptide interactions in interleukin-1 receptor system.

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Abstracts
EN
Interleukin-1 receptor antagonist (IL-1Ra) and vaccinia virus protein C10L share a VTXFYF motif, with X being Lys or Arg residue, respectively. Peptides of such sequence compete successfully with IL-1 for the cellular receptor. A pair of complementary peptides, based on the Siemion's hypothesis on the periodicity of the genetic code (QWLNIN and QWANIN), and another pair, in which, following the Root- Bernstein theory, Lys was used as complementary amino acid to Phe (QWLKIK and QWAKIK), were investigated for the peptide-antipeptide interactions using mass spectrometry (ESI-MS) and circular dichroism (CD) methods. The CD measurements indicated some conformational changes, more pronounced in the Siemion's pairs, however, no heterodimer formation was found by MS. In the region of IL-1 receptor situated close to the position of IL-1Ra in the IL-1Ra-receptor complex, a KQKL motif is present, suggesting a possibility of complementary recognition of the Root-Bernstein type in the IL-1 receptor. The biological activity of the complementary peptides is similar to that of the original ones. They efficiently compete with IL-1 and show moderate immunosuppressory activity in humoral and cellular immune response. The inhibition of the IL-1-IL-1 receptor interaction may result from the complementary peptides acting as mini-receptors with affinity for IL-1.
Publisher

Year
Volume
51
Issue
1
Pages
57-66
Physical description
Dates
published
2004
received
2003-10-31
revised
2004-02-26
accepted
2004-03-08
Contributors
  • Faculty of Chemistry, University of Wrocław, Wrocław, Poland
author
  • Faculty of Chemistry, University of Wrocław, Wrocław, Poland
  • Faculty of Chemistry, University of Wrocław, Wrocław, Poland
  • Faculty of Chemistry, University of Wrocław, Wrocław, Poland
  • Faculty of Chemistry, University of Wrocław, Wrocław, Poland
  • Institute of Immunology and Experimental Therapy, Wrocław, Poland
  • Faculty of Chemistry, University of Wrocław, Wrocław, Poland
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Document Type
Publication order reference
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YADDA identifier
bwmeta1.element.bwnjournal-article-abpv51i1p57kz
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