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2004 | 51 | 1 | 263-272
Article title

Morphological and immunological characterization of immunostimulatory complexes based on glycoglycerolipids from Laminaria japonica.

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EN
Abstracts
EN
Some physicochemical properties of glycoglycerolipids (monogalactosyldiacylglycerol, digalactosyldiacylglycerol and sulfoquinovosyldiacylglycerol) from the sea algae Laminaria japonica, as well as their ability to become incorporate into immunostimulating complexes (ISCOMs), used as a delivery system of microbial and tumor antigens in vesicular form, were studied. These glycolipids were found to differ essentially in fatty acid composition, unsaturation index and thermotropic behavior. The possibility of ISCOM modification by embedding the glycolipids studied instead of a phospholipid component in vesicles was shown. A preliminary research of the immunogenicity of the pore-forming protein from Yersinia pseudotuberculosis in modified (by monogalactosyldiacylglycerol) and typical (egg phosphatidylcholine) ISCOMs did not reveal a significant enhancement of immune response in comparison with that of isolated protein.
Publisher

Year
Volume
51
Issue
1
Pages
263-272
Physical description
Dates
published
2004
received
2003-12-02
revised
2004-02-11
accepted
2004-02-20
Contributors
author
  • Pacific Institute of Bioorganic Chemistry FEBRAS, Vladivostok, Russia
  • Pacific Institute of Bioorganic Chemistry FEBRAS, Vladivostok, Russia
author
  • Department of Biochemistry and Biotechnology, Far Eastern National University, Vladivostok, Russia
  • Department of Biochemistry and Biotechnology, Far Eastern National University, Vladivostok, Russia
  • Pacific Institute of Bioorganic Chemistry FEBRAS, Vladivostok, Russia
  • Pacific Institute of Bioorganic Chemistry FEBRAS, Vladivostok, Russia
  • Pacific Institute of Bioorganic Chemistry FEBRAS, Vladivostok, Russia
  • Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca, Salamanca, Spain
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv51i1p263kz
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