Biological evaluation of analogues of an insect neuropeptide proctolin.

• Authors: Iwona Woźnica , Wioletta Szeszel-Fedorowicz , Grzegorz Rosiński , Danuta Konopińska
• Languages of publication: EN

Abstracts

EN

Continuing our studies on proctolin (Arg-Tyr-Leu-Pro-Thr) we performed the synthesis and biological evaluation of 52 analogues substituted in position 2, 3, 4, and 5 of the peptide chain. The peptides were bioassayed for cardiotropic activity in vitro on Tenebrio molitor and myotropic activity on foregut of Schistocerca gregaria. Twenty analogues retained 20-80% of proctolin activity.

Keywords

EN

proctolin analogues; proctolin; insect myotropic peptide proctolin

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2004
• Volume: 51
• Issue: 1
• Pages: 115-119

Dates

published

2004

received

2003-10-31

revised

2004-01-23

accepted

2004-02-06

Contributors

author

Iwona Woźnica

• Faculty of Chemistry, University of Wrocław, Wrocław, Poland

author

Wioletta Szeszel-Fedorowicz

• Faculty of Chemistry, University of Wrocław, Wrocław, Poland

author

Grzegorz Rosiński

• Faculty of Chemistry, University of Wrocław, Wrocław, Poland

author

Danuta Konopińska

• Department of Animal Physiology, A. Mickiewicz University, Poznań, Poland

References

• Gray AS, Osborne RH, Jewess PJ. (1994) Pharmacology of proctolin receptors in the isolated foregut of the locust Schistocerca gregaria - identification of [N-methyl-L-tyrosine2]-proctolin as a potent receptor antagonist. J Insect Physiol.; 40: 595-600.
• Konopińska D, Rosiński G. (1999) Proctolin an insect neuropeptide. J Pept Sci.; 5: 533-46.
• Kuczer M, Rosiński G, Lisowski M, Picur B, Konopińska D. (1996) New proctolin analogues modified by D-amino acids in the peptide chain and their high cardioexcitatory effect on Tenebrio molitor. Int J Pept Protein Res.; 48: 286-91.
• Rosiński G, Gäde G. (1988) Hyperglycaemic and myoactive factors in the corpora cardiaca of the mealworm Tenebrio molitor. J Insect Physiol.; 33: 451-63.