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2004 | 51 | 1 | 115-119
Article title

Biological evaluation of analogues of an insect neuropeptide proctolin.

Content
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Languages of publication
EN
Abstracts
EN
Continuing our studies on proctolin (Arg-Tyr-Leu-Pro-Thr) we performed the synthesis and biological evaluation of 52 analogues substituted in position 2, 3, 4, and 5 of the peptide chain. The peptides were bioassayed for cardiotropic activity in vitro on Tenebrio molitor and myotropic activity on foregut of Schistocerca gregaria. Twenty analogues retained 20-80% of proctolin activity.
Publisher

Year
Volume
51
Issue
1
Pages
115-119
Physical description
Dates
published
2004
received
2003-10-31
revised
2004-01-23
accepted
2004-02-06
Contributors
  • Faculty of Chemistry, University of Wrocław, Wrocław, Poland
  • Faculty of Chemistry, University of Wrocław, Wrocław, Poland
  • Faculty of Chemistry, University of Wrocław, Wrocław, Poland
  • Department of Animal Physiology, A. Mickiewicz University, Poznań, Poland
References
  • Gray AS, Osborne RH, Jewess PJ. (1994) Pharmacology of proctolin receptors in the isolated foregut of the locust Schistocerca gregaria - identification of [N-methyl-L-tyrosine2]-proctolin as a potent receptor antagonist. J Insect Physiol.; 40: 595-600.
  • Konopińska D, Rosiński G. (1999) Proctolin an insect neuropeptide. J Pept Sci.; 5: 533-46.
  • Kuczer M, Rosiński G, Lisowski M, Picur B, Konopińska D. (1996) New proctolin analogues modified by D-amino acids in the peptide chain and their high cardioexcitatory effect on Tenebrio molitor. Int J Pept Protein Res.; 48: 286-91.
  • Rosiński G, Gäde G. (1988) Hyperglycaemic and myoactive factors in the corpora cardiaca of the mealworm Tenebrio molitor. J Insect Physiol.; 33: 451-63.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv51i1p115kz
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