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2003 | 50 | 4 | 985-1017
Article title

PDZ domains - common players in the cell signaling.

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EN
Abstracts
EN
PDZ domains are ubiquitous protein interaction modules that play a key role in cellular signaling. Their binding specificity involves recognition of the carboxyl-terminus of various proteins, often belonging to receptor and ion channel families. PDZ domains also mediate more complicated molecular networks through PDZ-PDZ interactions, recognition of internal protein sequences or phosphatidylinositol moieties. The domains often form a tandem of multiple copies, but equally often such tandems or single PDZ domain occur in combination with other signaling domains (for example SH3, DH/PH, GUK, LIM, CaMK). Common occurrence of PDZ domains in Metazoans strongly suggests that their evolutionary appearance results from the complication of signaling mechanisms in multicellular organisms. Here, we focus on their structure, specificity and role in signaling pathways.
Year
Volume
50
Issue
4
Pages
985-1017
Physical description
Dates
published
2003
received
2003-06-14
revised
2003-10-06
accepted
2003-10-09
References
  • Adamski FM, Zhu MY, Bahiraei F, Shieh BH. (1998) Interaction of eye protein kinase C and INAD in Drosophila. Localization of binding domains and electrophysiological characterization of a loss of association in transgenic flies. J Biol Chem.; 273: 17713-9.
  • Anzai N, Deval E, Schaefer L, Friend V, Lazdunski M, Lingueglia E. (2002) The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons. J Biol Chem.; 277: 16655-61.
  • Apperson ML, Moon IS, Kennedy MB. (1996) Characterization of densin-180, a new brain-specific synaptic protein of the O-sialoglycoprotein family. J Neurosci.; 16: 6839-52.
  • Baron A, Deval E, Salinas M, Lingueglia E, Voilley N, Lazdunski M. (2002) Protein kinase C stimulates the acid-sensing ion channel ASIC2a via the PDZ domain-containing protein PICK1. J Biol Chem.; 277: 50463-8.
  • Barritt DS, Pearn MT, Zisch AH, Lee SS, Javier RT, Pasquale EB, Stallcup WB. (2000) The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2. J Cell Biochem.; 79: 213-24.
  • Becamel C, Alonso G, Galeotti N, Demey E, Jouin P, Ullmer C, Dumuis A, Bockaert J, Marin P. (2002) Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach. EMBO J.; 21: 2332-42.
  • Beebe KD, Shin J, Peng J, Chaudhury C, Khera J, Pei D. (2000) Substrate recognition through a PDZ domain in tail-specific protease. Biochemistry.; 39: 3149-55.
  • Bezprozvanny I, Maximov A. (2001) Classification of PDZ domains. FEBS Lett.; 509: 457-62.
  • Bilder D, Perrimon N. (2000) Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature.; 403: 676-80.
  • Birrane G, Chung J, Ladias JA. (2003) Novel mode of ligand recognition by the Erbin PDZ domain. J Biol Chem.; 278: 1399-402.
  • Bitner-Glindzicz M, Lindley KJ, Rutland P, Blaydon D, Smith VV, Milla PJ, Hussain K, Furth-Lavi J, Cosgrove KE, Shepherd RM, Barnes PD, O'Brien RE, Farndon PA, Sowden J, Liu XZ, Scanlan MJ, Malcolm S, Dunne MJ, Aynsley-Green A, Glaser B. (2000) A recessive contiguous gene deletion causing infantile hyperinsulinism, enteropathy and deafness identifies the Usher type 1C gene. Nat Genet.; 26: 56-60.
  • Boeckers TM, Kreutz MR, Winter C, Zuschratter W, Smalla KH, Sanmarti-Vila L, Wex H, Langnaese K, Bockmann J, Garner CC, Gundelfinger ED. (1999) Proline-rich synapse-associated protein-1/cortactin binding protein 1 (ProSAP1/CortBP1) is a PDZ-domain protein highly enriched in the postsynaptic density. J Neurosci.; 19: 6506-18.
  • Boerkoel CF, Takashima H, Stankiewicz P, Garcia CA, Leber SM, Rhee-Morris L, Lupski JR. (2001) Periaxin mutations cause recessive Dejerine-Sottas neuropathy. Am J Hum Genet.; 68: 325-33.
  • Borg JP, Straight SW, Kaech SM, de Taddeo-Borg M, Kroon DE, Karnak D, Turner RS, Kim SK, Margolis B. (1998) Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting. J Biol Chem.; 273: 31633-6.
  • Borg JP, Marchetto S, Le Bivic A, Ollendorff V, Jaulin-Bastard F, Saito H, Fournier E, Adelaide J, Margolis B, Birnbaum D. (2000) ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor. Nat Cell Biol.; 2: 407-14.
  • Braithwaite SP, Xia H, Malenka RC. (2002) Differential roles for NSF and GRIP/ABP in AMPA receptor cycling. Proc Natl Acad Sci U S A.; 99: 7096-101.
  • Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, Huganir RL, Worley PF. (1997) Homer: a protein that selectively binds metabotropic glutamate receptors. Nature.; 386: 284-8.
  • Bredt DS. (1998) Sorting out genes that regulate epithelial and neuronal polarity. Cell.; 94: 691-4.
  • Brenman JE, Chao DS, Xia H, Aldape K, Bredt DS. (1995) Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy. Cell.; 82: 743-52.
  • Bruckner K, Pablo Labrador J, Scheiffele P, Herb A, Seeburg PH, Klein R. (1999) EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. Neuron.; 22: 511-24.
  • Bryant PJ, Huwe A. (2000) LAP proteins: what's up with epithelia? Nat Cell Biol.; 2: E141-3.
  • Butz S, Okamoto M, Sudhof TC. (1998) A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Cell.; 94: 773-82.
  • Cao TT, Deacon HW, Reczek D, Bretscher A, von Zastrow M. (1999) A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor. Nature.; 401: 286-90.
  • Chaib H, Rubin MA, Mucci NR, Li L, Taylor JMG, Day ML, Rhim JS, Macoska JA. (2001) Activated in prostate cancer: a PDZ domain-containing protein highly expressed in human primary prostate tumors. Cancer Res.; 61: 2390-4.
  • Chetkovich DM, Bunn RC, Kuo SH, Kawasaki Y, Kohwi M, Bredt DS. (2002) Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms. J Neurosci.; 22: 6415-25.
  • Christopherson KS, Hillier BJ, Lim WA, Bredt DS. (1999) PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain. J Biol Chem.; 274: 27467-73.
  • Cohen NA, Brenman JE, Snyder SH, Bredt DS. (1996) Binding of the inward rectifier K+ channel Kir 2.3 to PSD-95 is regulated by protein kinase A phosphorylation. Neuron.; 17: 759-67.
  • Cohen AR, Woods DF, Marfatia SM, Walther Z, Chishti AH, Anderson JM, Wood DF. (1998) Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells. J Cell Biol.; 142: 129-38.
  • Cuppen E, van Ham M, Pepers B, Wieringa B, Hendriks W. (1999) Identification and molecular characterization of BP75, a novel bromodomain-containing protein. FEBS Lett.; 459: 291-8.
  • Cuppen E, van Ham M, Wansink DG, de Leeuw A, Wieringa B, Hendriks W. (2000) The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL. Eur J Cell Biol.; 79: 283-93.
  • Daniels DL, Cohen AR, Anderson JM, Brunger AT. (1998) Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition. Nat Struct Biol.; 5: 317-25.
  • Daw MI, Chittajallu R, Bortolotto ZA, Dev KK, Duprat F, Henley JM, Collingridge GL, Isaac JT. (2000) PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC- dependent regulation of AMPA receptors at hippocampal synapses. Neuron.; 28: 873-86.
  • DeLano WL. The PyMOL Molecular Graphics System. DeLano Scientific LLC, San Carlos, CA, U S A. http://www.pymol.org
  • Dev KK, Nishimune A, Henley JM, Nakanishi S. (1999) The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits. Neuropharmacology.; 38: 635-44.
  • Dong H, O'Brien RJ, Fung ET, Lanahan AA, Worley PF, Huganir RL. (1997) GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors. Nature.; 386: 279-84.
  • Dong H, Zhang P, Song I, Petralia RS, Liao D, Huganir RL. (1999) Characterization of the glutamate receptor-interacting proteins GRIP1 and GRIP2. J Neurosci.; 19: 6930-41.
  • Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R. (1996) Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Cell.; 85: 1067-76.
  • Eck MJ, Dhe-Paganon S, Trub T, Nolte RT, Shoelson SE. (1996) Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor. Cell.; 85: 695-705.
  • Ellis RJ. (2001) Macromolecular crowding: an important but neglected aspect of the intracellular environment. Curr Opin Struct Biol.; 11: 114-9.
  • Erdmann KS, Kuhlmann J, Lessmann V, Herrmann L, Eulenburg V, Muller O, Heumann R. (2000) The adenomatous polyposis coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain. Oncogene.; 19: 3894-901.
  • Fallon L, Moreau F, Croft BG, Labib N, Gu WJ, Fon EA. (2002) Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain. J Biol Chem.; 277: 486-91.
  • Fanning AS, Anderson JM. (1999) PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane. J Clin Invest.; 103: 767-72.
  • Fuh G, Pisabarro MT, Li Y, Quan C, Lasky LA, Sidhu SS. (2000) Analysis of PDZ domain-ligand interactions using carboxyl-terminal phage display. J Biol Chem.; 275: 21486-91.
  • Garcia RA, Vasudevan K, Buonanno A. (2000) The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. Proc Natl Acad Sci U S A.; 97: 3596-601.
  • Garrard SM, Capaldo CT, Gao L, Rosen MK, Macara IG, Tomchick DR. (2003) Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6. EMBO J.; 22: 1125-33.
  • Gee SH, Quenneville S, Lombardo CR, Chabot J. (2000) Single-amino acid substitutions alter the specificity and affinity of PDZ domains for their ligands. Biochemistry.; 39: 14638-46.
  • Grootjans JJ, Zimmermann P, Reekmans G, Smets A, Degeest G, Durr J, David G. (1997) Syntenin, a PDZ protein that binds syndecan cytoplasmic domains. Proc Natl Acad Sci US A.; 94: 13683-8.
  • Grootjans JJ, Reekmans G, Ceulemans H, David G. (2000) Syntenin-syndecan binding requires syndecan-synteny and the co-operation of both PDZ domains of syntenin. J Biol Chem.; 275: 19933-41.
  • Gross C, Heumann R, Erdmann KS. (2001) The protein kinase C-related kinase PRK2 interacts with the protein tyrosine phosphatase PTP-BL via a novel PDZ domain binding motif. FEBS Lett.; 496: 101-4.
  • Guy PM, Kenny DA, Gill GN. (1999) The PDZ domain of the LIM protein enigma binds to beta-tropomyosin. Mol Biol Cell.; 10: 1973-84.
  • Hall RA, Premont RT, Chow CW, Blitzer JT, Pitcher JA, Claing A, Stoffel RH, Barak LS, Shenolikar S, Weinman EJ, Grinstein S, Lefkowitz RJ. (1998) The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange. Nature.; 392: 626-30.
  • Hall RA, Spurney RF, Premont RT, Rahman N, Blitzer JT, Pitcher JA, Lefkowitz RJ. (1999) G protein-coupled receptor kinase 6A phosphorylates the Na+/H+ exchanger regulatory factor via a PDZ domain-mediated interaction. J Biol Chem.; 274: 24328-34.
  • Hamazaki Y, Itoh M, Sasaki H, Furuse M, Tsukita S. (2002) Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule. J Biol Chem.; 277: 455-61.
  • Harris BZ, Lim WA. (2001) Mechanism and role of PDZ domains in signaling complex assembly. J Cell Sci.; 114: 3219-31.
  • Harris BZ, Hillier BJ, Lim WA. (2001) Energetic determinants of internal motif recognition by PDZ domains. Biochemistry.; 40: 5921-30.
  • Harris BZ, Lau FW, Fujii N, Guy RK, Lim WA. (2003) Role of electrostatic interactions in PDZ domain ligand recognition. Biochemistry.; 42: 2797-805.
  • Harrison SC. (1996) Peptide-surface association: the case of PDZ and PTB domains. Cell.; 86: 341-3.
  • Hata Y, Butz S, Sudhof TC. (1996) CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins. J Neurosci.; 16: 2488-94.
  • Hegedus T, Sessler T, Scott R, Thelin W, Bakos E, Varadi A, Szabo K, Homolya L, Milgram SL, Sarkadi B. (2003) C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins. Biochem Biophys Res Commun.; 302: 454-61.
  • Hillier BJ, Christopherson KS, Prehoda KE, Bredt DS, Lim WA. (1999) Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex. Science.; 284: 812-5.
  • Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK. (2002) The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. J Biol Chem.; 277: 15221-4.
  • Hoskins R, Hajnal AF, Harp SA, Kim SK. (1996) The C. elegans vulval induction gene lin-2 encodes a member of the MAGUK family of cell junction proteins. Development.; 122: 97-111.
  • Hsueh YP, Kim E, Sheng M. (1997) Disulfide-linked head-to-head multimerization in the mechanism of ion channel clustering by PSD-95. Neuron.; 18: 803-14.
  • Huber A, Sander P, Gobert A, Bahner M, Hermann R, Paulsen R. (1996a) The transient receptor potential protein (Trp), a putative store-operated Ca2+ channel essential for phosphoinositide-mediated photoreception, forms a signaling complex with NorpA, InaC and InaD. EMBO J.; 15: 7036-45.
  • Huber A, Sander P, Paulsen R. (1996b) Phosphorylation of the InaD gene product, a photoreceptor membrane protein required for recovery of visual excitation. J Biol Chem.; 271: 11710-7.
  • Hung TJ, Kemphues KJ. (1999) PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos. Development.; 126: 127-35.
  • Hwang JI, Heo K, Shin KJ, Kim E, Yun C, Ryu SH, Shin HS, Suh PG. (2000) Regulation of phospholipase C-β3 activity by Na+/H+ exchanger regulatory factor 2. J Biol Chem.; 275: 16632-7.
  • Irie M, Hata Y, Takeuchi M, Ichtchenko K, Toyoda A, Hirao K, Takai Y, Rosahl TW, Sudhof TC. (1997) Binding of neuroligins to PSD-95. Science.; 277: 1511-5.
  • Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S. (1999a) Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol.; 147: 1351-63.
  • Itoh M, Morita K, Tsukita S. (1999b) Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin. J Biol Chem.; 274: 5981-6.
  • Iwakura Y, Nagano T, Kawamura M, Horikawa H, Ibaraki K, Takei N, Nawa H. (2001) N-methyl-D-aspartate-induced α-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptor down-regulation involves interaction of the carboxyl terminus of GluR2/3 with Pick1. Ligand-binding studies using Sindbis vectors carrying AMPA receptor decoys. J Biol Chem.; 276: 40025-32.
  • Izawa I, Nishizawa M, Ohtakara K, Inagaki M. (2002) Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses. J Biol Chem.; 277: 5345-50.
  • Jaulin-Bastard F, Saito H, Le Bivic A, Ollendorff V, Marchetto S, Birnbaum D, Borg JP. (2001) The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins. J Biol Chem.; 276: 15256-63.
  • Jaulin-Bastard F, Arsanto JP, Le Bivic A, Navarro C, Vely F, Saito H, Marchetto S, Hatzfeld M, Santoni MJ, Birnbaum D, Borg JP. (2002) Interaction between Erbin and a Catenin-related protein in epithelial cells. J Biol Chem.; 277: 2869-75.
  • Jo K, Derin R, Li M, Bredt DS. (1999) Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex. J Neurosci.; 19: 4189-99.
  • Joberty G, Petersen C, Gao L, Macara IG. (2000) The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat Cell Biol.; 2: 531-9.
  • Kaech SM, Whitfield CW, Kim SK. (1998) The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells. Cell.; 94: 761-71.
  • Kanai F, Marignani PA, Sarbassova D, Yagi R, Hall RA, Donowitz M, Hisaminato A, Fujiwara T, Ito Y, Cantley LC, Yaffe MB. (2000) TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J.; 19: 6778-91.
  • Kang S, Xu H, Duan X, Liu JJ, He Z, Yu F, Zhou S, Meng XQ, Cao M, Kennedy GC. (2000) PCD1, a novel gene containing PDZ and LIM domains, is overexpressed in several human cancers. Cancer Res.; 60: 5296-302.
  • Kang BS, Cooper DR, Jelen F, Devedjiev Y, Derewenda U, Dauter Z, Otlewski J, Derewenda ZS. (2003) PDZ tandem of human syntenin. Crystal structure and functional properties. Structure (Camb).; 11: 459-68.
  • Karthikeyan S, Leung T, Ladias JA. (2001) Structural basis of the Na+/H+ exchanger regulatory factor PDZ1 interaction with the carboxyl-terminal region of the cystic fibrosis transmembrane conductance regulator. J Biol Chem.; 276: 19683-6.
  • Kavanaugh WM, Williams LT. (1994) An alternative to SH2 domains for binding tyrosine-phosphorylated proteins. Science.; 266: 1862-5.
  • Kennedy MB. (1995) Origin of PDZ (DHR, GLGF) domains. Trends Biochem Sci.; 20: 350.
  • Kim SK. (1997) Polarized signaling: basolateral receptor localization in epithelial cells by PDZ-containing proteins. Curr Opin Cell Biol.; 9: 853-9.
  • Kim CH, Chung HJ, Lee HK, Huganir RL. (2001) Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression. Proc Natl Acad Sci U S A.; 98: 11725-30.
  • Kim E, Niethammer M, Rothschild A, Jan YN, Sheng M. (1995) Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. Nature.; 378: 85-8.
  • Kimple ME, Siderovski DP, Sondek J. (2001) Functional relevance of the disulfide-linked complex of the N-terminal PDZ domain of InaD with NorpA. EMBO J.; 20: 4414-22.
  • Kishida S, Yamamoto H, Hino S, Ikeda S, Kishida M, Kikuchi A. (1999) DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability. Mol Cell Biol.; 19: 4414-22.
  • Klebes A, Knust E. (2000) A conserved motif in Crumbs is required for E-cadherin localisation and zonula adherens formation in Drosophila. Curr Biol.; 10: 76-85.
  • Koo TH, Lee JJ, Kim EM, Kim KW, Kim HD, Lee JH. (2002) Syntenin is overexpressed and promotes cell migration in metastatic human breast and gastric cancer cell lines. Oncogene.; 21: 4080-8.
  • Kornau HC, Schenker LT, Kennedy MB, Seeburg PH. (1995) Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science.; 269: 1737-40.
  • Koroll M, Rathjen FG, Volkmer H. (2001) The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity. J Biol Chem.; 276: 10646-54.
  • Kozlov G, Gehring K, Ekiel I. (2000) Solution structure of the PDZ2 domain from human phosphatase hPTP1E and its interactions with C-terminal peptides from the Fas receptor. Biochemistry.; 39: 2572-80.
  • Kozlov G, Banville D, Gehring K, Ekiel I. (2002) Solution structure of the PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with a peptide reveals contribution of the beta2-beta3 loop to PDZ domain-ligand interactions. J Mol Biol.; 320: 813-20.
  • Kurakin A, Bredesen D. (2002) Target-assisted iterative screening reveals novel interactors for PSD95, Nedd4, Src, Abl and Crk proteins. J Biomol Struct Dyn.; 19: 1015-29.
  • Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ. (1998) CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. Mol Cell Neurosci.; 11: 161-72.
  • Laura RP, Witt AS, Held HA, Gerstner R, Deshayes K, Koehler MF, Kosik KS, Sidhu SS, Lasky LA. (2002) The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF. J Biol Chem.; 277: 12906-14.
  • Lee SS, Glaunsinger B, Mantovani F, Banks L, Javier RT. (2000) Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins. J Virol.; 74: 9680-93.
  • Lemmers C, Medina E, Delgrossi MH, Michel D, Arsanto JP, Le Bivic A. (2002) hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells. J Biol Chem.; 277: 25408-15.
  • Liao DI, Qian J, Chisholm DA, Jordan DB, Diner BA. (2000) Crystal structures of the photosystem II D1 C-terminal processing protease. Nat Struct Biol.; 7: 749-53.
  • Lim S, Naisbitt S, Yoon J, Hwang JI, Suh PG, Sheng M, Kim E. (1999) Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development. J Biol Chem.; 274: 29510-8.
  • Lin D, Gish GD, Songyang Z, Pawson T. (1999) The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif. J Biol Chem.; 274: 3726-33.
  • Lin WJ, Chang YF, Wang WL, Huang CY. (2001) Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Cα-binding protein rPICK1. Biochem J.; 354: 635-43.
  • Lipinska B, Fayet O, Baird L, Georgopoulos C. (1989) Identification, characterization, and mapping of the Escherichia coli htrA gene, whose product is essential for bacterial growth only at elevated temperatures. J Bacteriol.; 171: 1574-84.
  • Mancini A, Koch A, Stefan M, Niemann H, Tamura T. (2000) The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity. FEBS Lett.; 482: 54-8.
  • Marfatia SM, Morais-Cabral JH, Kim AC, Byron O, Chishti AH. (1997) The PDZ domain of human erythrocyte p55 mediates its binding to the cytoplasmic carboxyl terminus of glycophorin C. Analysis of the binding interface by in vitro mutagenesis. J Biol Chem.; 272: 24191-7.
  • Martinez-Estrada OM, Villa A, Breviario F, Orsenigo F, Dejana E, Bazzoni G. (2001) Association of junctional adhesion molecule with calcium/calmodulin-dependent serine protein kinase (CASK/LIN-2) in human epithelial caco-2 cells. J Biol Chem.; 276: 9291-6.
  • Matsuda S, Mikawa S, Hirai H. (1999) Phosphorylation of serine-880 in GluR2 by protein kinase C prevents its C terminus from binding with glutamate receptor-interacting protein. J Neurochem.; 73: 1765-8.
  • Maudsley S, Zamah AM, Rahman N, Blitzer JT, Luttrell LM, Lefkowitz RJ, Hall RA. (2000) Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity. Mol Cell Biol.; 20: 8352-63.
  • Maximov A, Sudhof TC, Bezprozvanny I. (1999) Association of neuronal calcium channels with modular adaptor proteins. J Biol Chem.; 274: 24453-6.
  • Minton AP. (2000) Implications of macromolecular crowding for protein assembly. Curr Opin Struct Biol.; 10: 34-9.
  • Miyagi Y, Yamashita T, Fukaya M, Sonoda T, Okuno T, Yamada K, Watanabe M, Nagashima Y, Aoki I, Okuda K, Mishina M, Kawamoto S. (2002) Delphilin: a novel PDZ and formin homology domain-containing protein that synaptically colocalizes and interacts with glutamate receptor delta 2 subunit. J Neurosci.; 22: 803-14.
  • Mohler PJ, Kreda SM, Boucher RC, Sudol M, Stutts MJ, Milgram SL. (1999) Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50. J Cell Biol.; 147: 879-90.
  • Mok H, Shin H, Kim S, Lee JR, Yoon J, Kim E. (2002) Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins. J Neurosci.; 22: 5253-8.
  • Montell C. (2000) A PDZ protein ushers in new links. Nat Genet.; 26: 6-7.
  • Muhlhahn P, Zweckstetter M, Georgescu J, Ciosto C, Renner C, Lanzendorfer M, Lang K, Ambrosius D, Baier M, Kurth R, Holak TA. (1998) Structure of interleukin 16 resembles a PDZ domain with an occluded peptide binding site. Nat Struct Biol.; 5: 682-6.
  • Murdoch JN, Henderson DJ, Doudney K, Gaston-Massuet C, Phillips HM, Paternotte C, Arkell R, Stanier P, Copp AJ. (2003) Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse. Hum Mol Genet.; 12: 87-98.
  • Naisbitt S, Kim E, Tu JC, Xiao B, Sala C, Valtschanoff J, Weinberg RJ, Worley PF, Sheng M. (1999) Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin. Neuron.; 23: 569-82.
  • Niethammer M, Valtschanoff JG, Kapoor TM, Allison DW, Weinberg TM, Craig AM, Sheng M. (1998) CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90. Neuron.; 20: 693-707.
  • Oelmuller R, Herrmann RG, Pakrasi HB. (1996) Molecular studies of CtpA, the carboxyl-terminal processing protease for the D1 protein of the photosystem II reaction center in higher plants. J Biol Chem.; 271: 21848-52.
  • Ohtakara K, Nishizawa M, Izawa I, Hata Y, Matsushima S, Taki W, Inada H, Takai Y, Inagaki M. (2002) Densin-180, a synaptic protein, links to PSD-95 through its direct interaction with MAGUIN-1. Genes Cells.; 7: 1149-60.
  • Osten P, Khatri L, Perez JL, Kohr G, Giese G, Daly C, Schulz TW, Wensky A, Lee LM, Ziff EB. (2000) Mutagenesis reveals a role for ABP/GRIP binding to GluR2 in synaptic surface accumulation of the AMPA receptor. Neuron.; 27: 313-25.
  • Pallen MJ, Wren BW. (1997) The HtrA family of serine proteases. Mol Microbiol.; 26: 209-21.
  • Pallen MJ, Lam AC, Loman N. (2001) Tricorn-like proteases in bacteria. Trends Microbiol.; 9: 518-21.
  • Perez JL, Khatri L, Chang C, Srivastava S, Osten P, Ziff EB. (2001) PICK1 targets activated protein kinase Cα to AMPA receptor clusters in spines of hippocampal neurons and reduces surface levels of the AMPA- type glutamate receptor subunit 2. J Neurosci.; 21: 5417-28.
  • Ponting CP. (1997) Evidence for PDZ domains in bacteria, yeast, and plants. Protein Sci.; 6: 464-8.
  • Poulat F, Barbara PS, Desclozeaux M, Soullier S, Moniot B, Bonneaud N, Boizet B, Berta P. (1997) The human testis determining factor SRY binds a nuclear factor containing PDZ protein interaction domains. J Biol Chem.; 272: 7167-72.
  • Pupo AS, Minneman KP. (2002) Interaction of neuronal nitric oxide synthase with α1-adrenergic receptor subtypes in transfected HEK-293 cells. BMC Pharmacol.; 2: 17.
  • Raghuram V, Mak DD, Foskett JK. (2001) Regulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interaction. Proc Natl Acad Sci U S A.; 98: 1300-5.
  • Reina J, Lacroix E, Hobson SD, Fernandez-Ballester G, Rybin V, Schwab MS, Serrano L, Gonzalez C. (2002) Computer-aided design of a PDZ domain to recognize new target sequences. Nat Struct Biol.; 9: 621-7.
  • Roche JP, Packard MC, Moeckel-Cole S, Budnik V. (2002) Regulation of synaptic plasticity and synaptic vesicle dynamics by the PDZ protein Scribble. J Neurosci.; 22: 6471-9.
  • Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B. (2002) The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost. J Cell Biol.; 157: 161-72.
  • Ruff P, Chishti AH, Grimm E, Bischoff D, Kim AC. (1999) Exon skipping truncates the PDZ domain of human erythroid p55 in a patient with chronic myeloid leukemia in acute megakaryoblastic blast crisis. Leuk Res.; 23: 247-50.
  • Schneider S, Buchert M, Georgiev O, Catimel B, Halford M, Stacker SA, Baechi T, Moelling K, Hovens CM. (1999) Mutagenesis and selection of PDZ domains that bind new protein targets. Nat Biotechnol.; 17: 170-5.
  • Schuh K, Uldrijan S, Gambaryan S, Roethlein N, Neyses L. (2003) Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASK. J Biol Chem.; 278: 9778-83.
  • Schultz J, Hoffmuller U, Krause G, Ashurst J, Macias MJ, Schmieder P, Schneider-Mergener J, Oschkinat H. (1998a) Specific interactions between the syntrophin PDZ domain and voltage-gated sodium channels. Nat Struct Biol.; 5: 19-24.
  • Schultz J, Milpetz F, Bork P, Ponting CP. (1998b) SMART, a simple modular architecture research tool: identification of signaling domains. Proc Natl Acad Sci U S A.; 95: 5857-64.
  • Schultz J, Copley RR, Doerks T, Ponting CP, Bork P. (2000) SMART: a web-based tool for the study of genetically mobile domains. Nucleic Acids Res.; 28: 231-4.
  • Setou M, Nakagawa T, Seog DH, Hirokawa N. (2000) Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor- containing vesicle transport. Science.; 288: 1796-802.
  • Sherman DL, Fabrizi C, Gillespie CS, Brophy PJ. (2001) Specific disruption of a schwann cell dystrophin-related protein complex in a demyelinating neuropathy. Neuron.; 30: 677-87.
  • Shieh BH, Zhu MY. (1996) Regulation of the TRP Ca2+ channel by INAD in Drosophila photoreceptors. Neuron.; 16: 991-8.
  • Siemens J, Kazmierczak P, Reynolds A, Sticker M, Littlewood-Evans A, Muller U. (2002) The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions. Proc Natl Acad Sci U S A.; 99: 14946-51.
  • Silber KR, Keiler KC, Sauer RT. (1992) Tsp: a tail-specific protease that selectively degrades proteins with nonpolar C termini. Proc Natl Acad Sci U S A.; 89: 295-9.
  • Simske JS, Kaech SM, Harp SA, Kim SK. (1996) LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction. Cell.; 85: 195-204.
  • Songyang Z, Fanning AS, Fu C, Xu J, Marfatia SM, Chishti AH, Crompton A, Chan AC, Anderson JM, Cantley LC. (1997) Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science.; 275: 73-7.
  • Srivastava S, Osten P, Vilim FS, Khatri L, Inman G, States B, Daly C, DeSouza S, Abagyan R, Valtschanoff JG, Weinberg RJ, Ziff EB. (1998) Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP. Neuron.; 21: 581-91.
  • Staudinger J, Zhou J, Burgess R, Elledge SJ, Olson EN. (1995) PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system. J Cell Biol.; 128: 263-71.
  • Staudinger J, Lu J, Olson EN. (1997) Specific interaction of the PDZ domain protein PICK1 with the COOH terminus of protein kinase C-alpha. J Biol Chem.; 272: 32019-24.
  • Stricker NL, Christopherson KS, Yi BA, Schatz PJ, Raab RW, Dawes G, Bassett DE Jr, Bredt DS, Li M. (1997) PDZ domain of neuronal nitric oxide synthase recognizes novel C-terminal peptide sequences. Nat Biotechnol.; 15: 336-42.
  • Swiercz JM, Kuner R, Behrens J, Offermanns S. (2002) Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology. Neuron.; 35: 51-63.
  • Tang Y, Tang J, Chen Z, Trost C, Flockerzi V, Li M, Ramesh V, Zhu MX. (2000) Association of mammalian Trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF. J Biol Chem.; 275: 37559-64.
  • Tejedor FJ, Bokhari A, Rogero O, Gorczyca M, Zhang J, Kim E, Sheng M, Budnik V. (1997) Essential role for dlg in synaptic clustering of Shaker K+ channels in vivo. J Neurosci.; 17: 152-9.
  • Tochio H, Zhang Q, Mandal P, Li M, Zhang M. (1999) Solution structure of the extended neuronal nitric oxide synthase PDZ domain complexed with an associated peptide. Nat Struct Biol.; 6: 417-21.
  • Torres R, Firestein BL, Dong H, Staudinger J, Olson EN, Huganir RL, Bredt DS, Gale NW, Yancopoulos GD. (1998) PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. Neuron.; 21: 1453-63.
  • Torres GE, Yao WD, Mohn AR, Quan H, Kim KM, Levey AI, Staudinger J, Caron MG. (2001) Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. Neuron.; 30: 121-34.
  • Tsunoda S, Sierralta J, Sun Y, Bodner R, Suzuki E, Becker A, Socolich M, Zuker CS. (1997) A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade. Nature.; 388: 243-9.
  • Tsunoda S, Sierralta J, Zuker CS. (1998) Specificity in signaling pathways: assembly into multimolecular signaling complexes. Curr Opin Genet Dev.; 8: 419-22.
  • Tu JC, Xiao B, Naisbitt S, Yuan JP, Petralia RS, Brakeman P, Doan A, Aakalu VK, Lanahan AA, Sheng M, Worley PF. (1999) Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron.; 23: 583-92.
  • Ullmer C, Schmuck K, Figge A, Lubbert H. (1998) Cloning and characterization of MUPP1, a novel PDZ domain protein. FEBS Lett.; 424: 63-8.
  • Vaccaro P, Dente L. (2002) PDZ domains: troubles in classification. FEBS Lett.; 512: 345-9.
  • Vaccaro P, Brannetti B, Montecchi-Palazzi L, Philipp S, Helmer Citterich M, Cesareni G, Dente L. (2001) Distinct binding specificity of the multiple PDZ domains of INADL, a human protein with homology to INAD from Drosophila melanogaster. J Biol Chem.; 276: 42122-30.
  • Vallenius T, Luukko K, Makela TP. (2000) CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4. J Biol Chem.; 275: 11100-5.
  • Vallenius T, Makela TP. (2002) Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ- LIM protein. J Cell Sci.; 115: 2067-73.
  • van Huizen R, Miller K, Chen DM, Li Y, Lai ZC, Raab RW, Stark WS, Shortridge RD, Li M. (1998) Two distantly positioned PDZ domains mediate multivalent INAD- phospholipase C interactions essential for G protein-coupled signaling. EMBO J.; 17: 2285-97.
  • Venter JC, et al. (2001) The sequence of the human genome. Science.; 291: 1304-51.
  • Verpy E, Leibovici M, Zwaenepoel I, Liu XZ, Gal A, Salem N, Mansour A, Blanchard S, Kobayashi I, Keats BJ, Slim R, Petit C. (2000) A defect in harmonin, a PDZ domain-containing protein expressed in the inner ear sensory hair cells, underlies Usher syndrome type 1C. Nat Genet.; 26: 51-5.
  • Voltz JW, Weinman EJ, Shenolikar S. (2001) Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation. Oncogene.; 20: 6309-14.
  • Wallace AC, Laskowski RA, Thornton JM. (1995) LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. Protein Eng.; 8: 127-34.
  • Walma T, Spronk CA, Tessari M, Aelen J, Schepens J, Hendriks W, Vuister GW. (2002) Structure, dynamics and binding characteristics of the second PDZ domain of PTP-BL. J Mol Biol.; 316: 1101-10.
  • Wang S, Yue H, Derin RB, Guggino WB, Li M. (2000) Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity. Cell.; 103: 169-79.
  • Weinman EJ, Steplock D, Donowitz M, Shenolikar S. (2000) NHERF associations with sodium-hydrogen exchanger isoform 3 (NHE3) and ezrin are essential for cAMP-mediated phosphorylation and inhibition of NHE3. Biochemistry.; 39: 6123-9.
  • Whitfield CW, Benard C, Barnes T, Hekimi S, Kim SK. (1999) Basolateral localization of the Caenorhabditis elegans epidermal growth factor receptor in epithelial cells by the PDZ protein LIN-10. Mol Biol Cell.; 10: 2087-100.
  • Wolf G, Trub T, Ottinger E, Groninga L, Lynch A, White MF, Miyazaki M, Lee J, Shoelson SE. (1995) PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities. J Biol Chem.; 270: 27407-10.
  • Woods DF, Hough C, Peel D, Callaini G, Bryant PJ. (1996) Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epithelia. J Cell Biol.; 134: 1469-82.
  • Wyszynski M, Kim E, Yang FC, Sheng M. (1998) Biochemical and immunocytochemical characterization of GRIP, a putative AMPA receptor anchoring protein, in rat brain. Neuropharmacology.; 37: 1335-44.
  • Wyszynski M, Kim E, Dunah AW, Passafaro M, Valtschanoff JG, Serra-Pages C, Streuli M, Weinberg RJ, Sheng M. (2002) Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting. Neuron.; 34: 39-52.
  • Xia H, Winokur ST, Kuo WL, Altherr MR, Bredt DS. (1997) Actinin-associated LIM protein: identification of a domain interaction between PDZ and spectrin-like repeat motifs. J Cell Biol.; 139: 507-15.
  • Xia J, Zhang X, Staudinger J, Huganir RL. (1999) Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1. Neuron.; 22: 179-87.
  • Xia J, Chung HJ, Wihler C, Huganir RL, Linden DJ. (2000) Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins. Neuron.; 28: 499-510.
  • Xu XZ, Choudhury A, Li X, Montell C. (1998) Coordination of an array of signaling proteins through homo- and heteromeric interactions between PDZ domains and target proteins. J Cell Biol.; 142: 545-55.
  • Yanagisawa J, Takahashi M, Kanki H, Yano-Yanagisawa H, Tazunoki T, Sawa E, Nishitoba T, Kamishohara M, Kobayashi E, Kataoka S, Sato T. (1997) The molecular interaction of Fas and FAP-1. A tripeptide blocker of human Fas interaction with FAP-1 promotes Fas-induced apoptosis. J Biol Chem.; 272: 8539-45.
  • Yao I, Hata Y, Ide N, Hirao K, Deguchi M, Nishioka H, Mizoguchi A, Takai Y. (1999) MAGUIN, a novel neuronal membrane-associated guanylate kinase-interacting protein. J Biol Chem.; 274: 11889-96.
  • Zhang Q, Fan JS, Zhang M. (2001) Interdomain chaperoning between PSD-95, Dlg, and Zo-1 (PDZ) domains of glutamate receptor-interacting proteins. J Biol Chem.; 276: 43216-20.
  • Zhou MM, Ravichandran KS, Olejniczak EF, Petros AM, Meadows RP, Sattler M, Harlan JE, Wade WS, Burakoff SJ, Fesik SW. (1995) Structure and ligand recognition of the phosphotyrosine binding domain of Shc. Nature.; 378: 584-92.
  • Zhou MM, Huang B, Olejniczak ET, Meadows RP, Shuker SB, Miyazaki M, Trub T, Shoelson SE, Fesik SW. (1996) Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain. Nat Struct Biol.; 3: 388-93.
  • Zhou Q, Ruiz-Lozano P, Martone ME, Chen J. (1999) Cypher, a striated muscle-restricted PDZ and LIM domain-containing protein, binds to alpha-actinin-2 and protein kinase C. J Biol Chem.; 274: 19807-13.
  • Zimmermann P, Meerschaert K, Reekmans G, Leenaerts I, Small JV, Vandekerckhove J, David G, Gettemans J. (2002) PIP(2)-PDZ domain binding controls the association of syntenin with the plasma membrane. Mol Cell.; 9: 1215-25.
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