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2003 | 50 | 4 | 1147-1154
Article title

Selenium, glutathione and glutathione peroxidases in blood of patients with chronic liver diseases.

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EN
Abstracts
EN
Disturbances in the antioxidant system could play a role in pathogenesis of chronic liver disease. The aim of our study was to evaluate the levels/activities of antioxidants in blood of patients with chronic liver disease. We estimated selenium and glutathione concentrations and glutathione peroxidase activities in blood of 59 patients with chronic hepatitis B or C virus infection (group 1) and 64 patients with alcoholic, autoimmune or cryptogenic chronic liver disease (group 2). The results were compared with 50 healthy controls. Whole blood and plasma selenium and red cell glutathione concentrations were significantly lower in the patients compared with the controls. Red cell glutathione peroxidase activity was slightly reduced in both subgroups of group 1 and in group 2 with normal alanine aminotransferase values. Plasma glutathione peroxidase activity was slightly but significantly higher in patients with elevated aminotransferase values. The findings suggest that disturbances in antioxidant parameters in blood of patients with chronic liver disease may be the cause of the peroxidative damage of cells.
Publisher

Year
Volume
50
Issue
4
Pages
1147-1154
Physical description
Dates
published
2003
received
2003-09-24
revised
2003-11-27
accepted
2003-12-09
Contributors
  • Department of Biochemistry, The Ludwik Rydygier Medical University in Bydgoszcz, Bydgoszcz, Poland
  • Department of Biochemistry, The Ludwik Rydygier Medical University in Bydgoszcz, Bydgoszcz, Poland
  • Department of Infectious Diseases, The Ludwik Rydygier Medical University in Bydgoszcz, Bydgoszcz, Poland
  • Department of Infectious Diseases, The Ludwik Rydygier Medical University in Bydgoszcz, Bydgoszcz, Poland
  • Department of Biochemistry, The Ludwik Rydygier Medical University in Bydgoszcz, Bydgoszcz, Poland
References
  • Akkus I, Gültekin F, Aköz M, Cağlayan O, Bahcaci S, Gülsüm C, Ay M, Gürel A. (1997) Effect of moderate alcohol intake on lipid peroxidation in plasma, erythrocyte and leukocyte and on some antioxidant enzymes. Clin Chim Acta.; 266: 141-7.
  • Avissar N, Ornt DB, Yagil Y, Horowitz S, Watkins RH, Kerl EA. (1994) Human kidney proximal tubules are the main source of plasma glutathione peroxidase. Am J Physiol.; 266: C367-75.
  • Behne D, Kyriakopoulos A. (2001) Mammalian selenium-containing proteins. Annu Rev Nutr.; 21: 453-73.
  • Beutler E. (1971) Red cell metabolism. In A manual of biochemical methods. Beutler E, ed, pp 11-2. Grune-Stratton, New York.
  • Bianchi G, Bugianesi E, Ronchi M, Fabbri A, Zoli M, Marchesini G. (1997) Glutathione kinetics in normal man and in patients with liver cirrhosis. J Hepatol.; 26: 606-13.
  • Buljevac M, Romić Ź, Vucelić B, Banić M, Krznarić Ż, Plešsko S. (1996) Serum selenium concentration in patients with liver cirrhosis and hepatocellular carcinoma. Acta Med Croatica.; 50: 11-4.
  • Burk RF, Early DS, Hill KE, Palmer IS, Boeglin ME. (1998) Plasma selenium in patients with cirrhosis. Hepatology.; 27: 794-8.
  • Burk RF, Hill KE. (1999) Orphan selenoproteins. BioEssays.; 21: 231-7.
  • Clot P, Tabone M, Arico S, Albano E. (1994) Monitoring oxidative damage in patients with liver cirrhosis and different daily alcohol intake. Gut.; 35: 1637-43.
  • Deagan JT, Butler JA, Zachara BA, Whanger PD. (1993) Determination of the distribution of selenium between glutathione peroxidase, selenoprotein P, and albumin in plasma. Anal Biochem.; 208: 176-81.
  • Dworkin BM, Rosenthal WS, Gordon GG, Jankowski RH. (1984) Diminished blood selenium levels in alcoholics. Alcohol Clin Exp Res.; 8: 535-8.
  • Dworkin B, Rosenthal WS, Jankowski RH, Gordon GG, Haldea D. (1985) Low blood selenium levels in alcoholics with and without advanced liver disease. Correlations with clinical and nutritional status. Digest Dis Sci.; 30: 838-44.
  • Girre C, Hispard E, Therond P, Guedj S, Bourdon R, Dally S. (1990) Effect of abstinence from alcohol on the depression of glutathione peroxidase activity and selenium and vitamin E levels in chronic alcoholic patients. Alcohol Clin Exp Res.; 14: 909-12.
  • Grattagliano I, Vendemiale G, Sabba C, Buonamico P, Altomare E. (1996) Oxidation of circulating proteins in alcoholics: role of acetaldehyde and xantine oxidase. J Hepatol.; 25: 28-36.
  • Guarini P, Stanzial AM, Olivieri O, Casaril M, Galvani S, Pantalena M, Corrocher R. (1998) Erythrocyte membrane lipids and serum selenium in post-viral and alcoholic cirrhosis. Clin Chim Acta.; 270: 139-50.
  • Guemouri L, Lecomte E, Herbeth B, Pirollet P, Paille F, Siest G, Artur Y. (1993) Blood activities of antioxidant enzymes in alcoholics before and after withdrawal. J Stud Alcohol.; 54: 626-9.
  • Holben DH, Smith AM. (1999) The diverse role of selenium within selenoproteins. A review. J Am Diet Assoc.; 99: 836-43.
  • Inoue M. (1994) Protective mechanism against reactive oxygen species. In The liver: biology and pathobiology. Arias IM, Boyer JL, Fausto N, Jacoby WB, Schachter DA, Shafritz DA, eds, pp 443-59. Raven Press Ltd, New York.
  • Johansson U, Johnsson F, Joelsson B, Berglund M, Akesson B. (1986) Selenium status in patients with liver cirrhosis and alcoholism. Brit J Nutr.; 55: 227-33.
  • Loguercio C, De Girolamo V, Federico A, Feng SL, Cataldi V, Del Vecchio Blanco C, Gialanella G. (1997) Trace elements and chronic liver diseases. J Trace Elem Med Biol.; 11: 158-61.
  • Moron MS, Depierre JW, Mannervik B. (1979) Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta.; 582: 67-78.
  • Oh SI, Kim CI, Chun HJ, Lee MS, Park SC. (1997) Glutathione recycling is attenuated by acute ethanol feeding in rat liver. J Korean Med Sci.; 12: 316-21.
  • Paglia DE, Valentine WN. (1967) Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med.; 70: 158-69.
  • Rayman MP. (2000) The importance of selenium to human health. Lancet.; 356: 233-41.
  • Schwarz K, Foltz CM. (1957) Selenium as an integral part of factor 3 against dietary necrotic liver degeneration. J Am Chem Soc.; 79: 3292-3.
  • Świętek K, Juszczyk J. (1997) Reduced glutathione concentration in erythrocytes of patients with acute and chronic viral hepatitis. J Viral Hepat.; 4: 139-41.
  • Tanner AR, Bantock I, Hinks L, Lloyd B, Turner NR, Wright R. (1986) Depressed selenium and vitamin E levels in an alcoholic population. Possible relationship to hepatic injury through increased lipid peroxidation. Dig Dis Sci.; 31: 1307-12.
  • Watkinson JH. (1966) Fluorometric determination of selenium in biological material with 2,3-diaminonaphthalene. Anal Chem.; 38: 92-7.
  • Whanger PD. (1998) Metabolism of selenium in humans. J Trace Elem Exp Med.; 11: 227-40.
  • Xia Y, Ha P, Hill K, Butler J, Whanger P. (2000) Distribution of selenium between fractions in erythrocytes, plasma, hair, and fingernails of Chinese women living in selenium-deficient, -adequate, and -excessive areas of China. J Trace Elem Exp Med.; 13: 333-42.
  • Zachara BA, Pawluk H, Bloch-Bogusławska E, Śliwka KM, Korenkiewicz J, Skok Ź, Ryć K. (2001) Tissue level, distribution, and total body selenium content in healthy humans and in some diseases in Poland. Arch Environ Health.; 56: 461-6.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv50i4p1147kz
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