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2003 | 50 | 3 | 883-890
Article title

YOR129c, a new element interacting with Cnm67p, a component of the spindle pole body of Saccharomyces cerevisiae.

Content
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EN
Abstracts
EN
The Saccharomyces cerevisiae spindle pole body (SPB) consists of numerous proteins forming the outer, inner and central plaques. The protein Cnm67 is an important component of the outer plaque. The C-terminus of this protein contains a determinant important for its SPB localization. We identified a protein encoded by YOR129c which interacts with this C-terminus in the two-hybrid system. YOR129c and CNM67 exhibit weak genetic interaction. The double deletion strain yor129cΔ cnm67Δ exhibits moderately increased resistance to 0.1 M LiCl and hygromycin B compared with the cnm67Δ single mutant. We propose that the YOR129c protein is an accessory factor associated with the cytoplasmic face of SPB and plays a role in cation homeostasis and/or multidrug resistance.
Year
Volume
50
Issue
3
Pages
883-890
Physical description
Dates
published
2003
received
2003-06-26
revised
2003-08-11
accepted
2003-08-19
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Document Type
Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv50i3p883kz
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