Signal transducer and activator of transcription STAT3 plays a major role in gp130-mediated acute phase protein gene activation.

• Authors: Petra May , Ute Schniertshauer , Claudia Gerhartz , Friedemann Horn , Peter C Heinrich
• Languages of publication: EN

Abstracts

EN

Interleukin-6 is a potent inducer of acute-phase response gene transcription. The intracellular signal transduction mechanisms by which this and other biological effects of the cytokine are achieved include activation of the JAK-STAT signaling pathway. More specifically, activation of the signal transducers and activators of transcription STAT1, 3, and 5 in response to IL-6 has been described. We examined the relative potency of these three STAT factors for the activation of acute-phase gene promoters in HepG2 cells in a reporter gene-based assay, where specific STAT factors could be activated via recombinant receptor constructs bearing different STAT-recruiting modules. These experiments indicate that amongst the STAT factors known to be activated by IL-6 STAT3 is the most potent activator of acute-phase gene transcription.

Keywords

EN

immediate early genes; STAT transcription factors; acute phase proteins; gp130

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2003
• Volume: 50
• Issue: 3
• Pages: 595-601

Dates

published

2003

received

2003-05-30

revised

2003-08-29

accepted

2003-09-8

Contributors

author

Petra May

• Department of Biochemistry, Universitätsklinikum, Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany

author

Ute Schniertshauer

• Department of Biochemistry, Universitätsklinikum, Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany

author

Claudia Gerhartz

• Department of Biochemistry, Universitätsklinikum, Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany

author

Friedemann Horn

• Department of Biochemistry, Universitätsklinikum, Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany

author

Peter C Heinrich

• Department of Biochemistry, Universitätsklinikum, Rheinisch-Westfälische Technische Hochschule Aachen, Aachen, Germany

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