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2003 | 50 | 2 | 549-553
Article title

Cellular level of 8-oxo-2'-deoxyguanosine in DNA does not correlate with urinary excretion of the modified base/nucleoside.

Content
Title variants
Languages of publication
EN
Abstracts
EN
We assessed a relationship between the level of 8-oxodG in leukocyte DNA measured with the high performance liquid chromatography with electrochemical detection (HPLC/EC) technique and urinary excretion of the modified nucleoside/base analysed with a recently developed methodology involving HPLC prepurification followed by gas chromatography with isotope dilution mass spectrometric detection. No correlation was found between these markers of oxidative DNA damage commonly used in epidemiological studies. Several possible explanations of this finding are discussed.
Publisher

Year
Volume
50
Issue
2
Pages
549-553
Physical description
Dates
published
2003
received
2003-02-12
revised
2003-05-21
accepted
2003-05-30
Contributors
  • Department of Clinical Biochemistry, The Ludwik Rydygier Medical University in Bydgoszcz, Bydgoszcz, Poland
  • Department of Clinical Biochemistry, The Ludwik Rydygier Medical University in Bydgoszcz, Bydgoszcz, Poland
  • Department of Clinical Biochemistry, The Ludwik Rydygier Medical University in Bydgoszcz, Bydgoszcz, Poland
  • Department of Clinical Biochemistry, The Ludwik Rydygier Medical University in Bydgoszcz, Bydgoszcz, Poland
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-abpv50i2p549kz
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